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Acta Scientific Pharmaceutical Sciences

Journal Papers (25) Details Call for Paper Manuscript submission Publication Ethics Contact Authors' Guide Line
1 COVID-19: An Overview about the Disease Etiology and its Prevention , Nayab Mustansar and Rizwan Rafi
Coronaviruses are zoonotic, meaning they are transmitted between animals and people. Common signs of infection include respi-ratory symptoms, fever, cough, shortness of breath and breathing difficulties [2]. In more severe cases, infection can cause pneumo-nia, severe acute respiratory syndrome, kidney failure and even death [3].Detailed investigations found that SARS-CoV was transmitted from civet cats to humans and MERS-CoV from dromedary camels to humans. Several known coronaviruses are circulating in animals that have not yet infected humans [1-3].This article is based on the overview regarding the disease etiology and its prevention to educate the mass population.
2 Recommendation for Compassionate Use of One or More of the Three Medications for Covid-19 Patients on the Verge of Dying , Tapan K Chaudhuri, Tushar K Chowdhury, Tandra R Chaudhuri, Taposh K Chowdhury and Bulu R Chowdhury
At the rate the COVID-19 patients are dying - like one death every 10 minutes in some country - there is an urgency to invoke compassionate treatment for dying COVID-19 patients with one or more of the following three modalities without waiting for going through rules, regulations or red tape (fast-track treatment)
3 A Comparative Study on Photocatalytic Activity of ZnO, ZnS and ZnO-ZnS Composite , Basant Kumar Menariya
A comparative study was made on photocatalytic activity of ZnO, ZnS and their composite. A simple mechanochemical method was used for preparation of composite. The photocatalytic efficiency of ZnO-ZnS composite was compared with pure ZnO and ZnS. The effect of various parameters such as pH, dye concentration, semiconductor amount and light intensity was observed. The opti-mum conditions for this degradation were obtained as: Rose Bengal = 7.0 × 10-6M, pH = 7.5, amount of composite = 0.08g and light intensity = 60.0 mWcm-2. It was found that coupled chalcogenide ZnO-ZnS show better photocatalytic activity as compared with ZnO and ZnS alone for the degradation of rose Bengal in the presence of visible light.
4 Histological Changes in Lung Induced by Single Intratracheal Instillation on Bleomycin in Wistar Rats , Ramesh Verma1, Poonam Mehta, Vishvesh Dalal, Manish V Patel, Parnav Buch, Pratyush Patankar and Suresh Balakrishnan
The present study examined the histological changes in lung tissue induced by single intratracheal instillation on bleomycin in Wi-star rats. Animals were treated with bleomycin at the dose of 6.5 U/kg body weight via., single intra-tracheal instillation. Histopatho-logical abnormalities in lungs were assessed on day 21 using hematoxylin and eosin staining and Masson’s trichrome staining. Single intra-tracheal instillation of bleomycin led to the extensive deposition of collagen in peribronchial and perialveolar region, which obliterated the alveolar spaces. Severe lung alveolitis and injury, which was manifested with interalveolar inflammation, thickening alveolar wall, bronchial erosion, and large fibrotic area inconsistently. The results of the present study speculate that inflammation is the forerunner of fibrosis induced by single intra-tracheal instillation of bleomycin.
5 The Pathogenesis of Multiple Sclerosis , Gejalakshmi S and Harikrishnan N
An array of recently published manuscript globally have proposed the stages of different pathogenic pathways in multiple sclero-sis. These research were focused on both biopsy and autopsy. Based the review data on clinical, imaging and cerebrospinal fluid sug-gest that most of the cases were disseminated encephalomyelitis rather than MS pathogenesis. Cognitive impairment is a common and disabling feature of multiple sclerosis. It may contribute to withdrawal from work than physical disability. The article delivers the importance for early diagnosis and management of disabilities in MS, before it develops an irreversible entry.
6 Drug Addiction and their Management: An Overview , Anuradha Sharma and Amar Chaudhary
Drug addiction could be a term that means compulsive physiological want for use of a habit-forming substance, which is charac-terized by tolerance and well-defined physiological symptoms upon withdrawal. In this communication, the author has compiled all the drugs used for addiction, various tests for determination of addiction and their management
7 History, Symptoms and Preventive Measures of Coronavirus Disease-19 (COVID-19): Mini Review , Mohd Asif Khan and Deeksha Sahai
In 1968, term ‘coronavirus’ was first coined. It shows crown-like morphology when observed under electron microscope. CoVs are summarized into four genera such as Alphacoronavirus, Betacoronavirus, Gammacoronavirus and Deltacoronavirus. Betacoronavi-rus was further classified into four lineages A, B, C and D. Total 06 species of human coronaviruses have been discovered including OC43, 229E, NL63, HKU1, SARS-CoV and MERS-CoV. A novel (new) coronavirus is recently discovered in December 2019 in Wuhan city of China. The coronavirus belongs to family- Coronaviridae; largest family in Nidovirales order. Chinese authority declared it as a novel coronavirus (nCoV-19). MERS-CoV was detected in camel serum- being almost identical to human coronaviruses. Bats have been a natural reservoir of coronaviruses lineages and thought as ancestor for all coronavirus lineages. In India, 9 deaths have been reported till 24 March 2020. The Print reports that with current rate India can see 30000 COVID-19 deaths by May, as no hospital bed by June. It concludes that its clinical signs and symptoms are almost similar to pneumonia. It indicates to researchers to work on genetic configuration (genome) of coronavirus to develop more specific vaccine to save life of society and world.
8 Nicotinamide, Folic Acid and Derivatives as Potent Inhibitors of Inflammatory Factors against Novel Corona Virus Infection , Hemanth Kumar Manikyam and Sunil K Joshi
A novel coronavirus designated as SARS-CoV-2 in February 2020 by World Health organization (WHO) was identified as main cause of SARS like pneumonia cases in Wuhan city in Hubei Prov-ince of China at the end of 2019. This been recently declared as Global Pandemic by WHO. There is a global emergency to identi-fy potential drugs to treat the SARS-CoV-2. Currently, there is no specific treatment against the new virus. There is an emergency to identifying potential antiviral agents to combat the disease is urgently needed. An effective and quick approach is to test exist-ing antiviral drugs against COVID-19. Patients affected with Novel coronavirus had shown severe respiratory inflammatory burst which includes sever cytokine and lymphocyte over responses. Particularly interleukins swarm like IL8, IL2, IL6 and other inflam-matory triggering factors.
9 Antimicrobial Activity of Ciprofloxacin-Loaded Softisan-154 Lipid Microparticles: Physicochemical Evaluation and In Vitro Activity , Momoh A Mumuni, Nafiu Aminu, Frankline C Kenechukwu, Agboke A Ayodeji, Adedokun M Oluseun, Oyeniyi Y James, Parom K Stephen, Obajuluwa A Funke, Usman Muhammad, Darlington Youngson, Tochimen K Michel, Omeje C Ernest and Emmanuel C Ibezim
The objective of this work was to prepare and investigate in vitro ciprofloxacin (CPX)-loaded solid lipid microparticles (SLM) against some selected micro-organisms for improved activity. Lipid matrix consisting of Softisan®-154 and Phospholipon® 90H was used to prepare SLMs loaded with CPX. The thermal properties of polymers and the SLMs were determined by a differential scanning calorimetry (DSC), particles size and the pH change of CPX-loaded SLMs were evaluated. The encapsulation efficiency (EE), load-ing capacity (LC) and in vitro release of CPX from the SLMs were evaluated. The antimicrobial activities of the SLM against selected organisms were determined. Characterizations showed that lipid matrix generated imperfect microstructure that accommodated CPX in a concentration-dependent manner. The EE and LC% were 89.2 and 33%, respectively. Maximum CPX release of > 80% was obtained in batch A3. The antimicrobial activity of the formulation against the tested organisms was comparably higher in batch C (49.10 ± 2.10) against S. aureus and (33.10 ± 0.21 mm) against S. typhii as compared to the reference sample. This result suggests the capability of the SLMs to modify the release of the drug and improve its activities against the microorganisms.
10 Transition Metal Complexes of Schiff Base Ligand Derived from Trimethoprim with Cyclohexanone: Synthesis, Characterization, Antimicrobial and Computational Studies , Hussaini Garba, Jamila Bashir Yakasai, Ibrahim Waziri and Ibraheem O Bisiriyu
In this study, Metal (II) Complexes of Mn (II), Fe (III), Co (II) and Ni (II) with Schiff base ligand derived from Trimethoprim and Cyclohexanone were synthesized and characterized using various physic-chemical techniques such as: solubility, conductivity, melt-ing point determination, UV/Vis and Fourier transform infrared, 1H-NMR and elemental analysis. On the basis of these character-izations, a six coordinated octahedral geometry has been proposed for all the complexes. The Schiff base ligand and its complexes were screened for their antimicrobial activity against some pathogenic microbial isolate and compared with the parent drug. The antimicrobial activity results showed the following trend: metal complexes > Schiff base ligands > Parent drugs. This suggests poten-tial antimicrobials agents with broad spectrum activity. Computational studies further revealed that M-Cl bond is responsible for the trend in antimicrobial properties among the complexes
11 Forecasting Future of Manufacturing Systems Driven by Artificial Intelligence: Recent Progress and Future Directions , Bahman Zohuri and Farhang Mossavar Rahmani
The start of a new decade brings a new wave of technological change and unprecedented opportunities that will generate massive amounts of data at the level of Big Data (BD), spawn new threats and transform the way we do business. Dealing with such enormous data structurally or unstructured-wise and process it in real-time requires a new innovative technology such as Artificial Intelligence (AI). Today, AI is capable of learning from its experience through the element of its Machine Learning (ML) in conjunction with the Deep Learning (DL) component and using them to adjust to new input and perform human-like performance, or at least to comple-ment and enhance human abilities. Because of this capability, it encompasses every aspect of the enterprise in the years to come. That is why we believe AI, Automation, and Analytics are central to the success of the enterprise and encompass critical business areas, including data, business processes, the workforce, and risk and reputation
12 Artificial Intelligence Versus Human Intelligence: A New Technological Race , Bahman Zohuri and Farhang Mossavar Rahmani
Today, artificial intelligence (AI) is capable of learning from its experience through the element of its Machine Learning (ML) in conjunction with Deep Learning (DL) component and using them to adjust to new input and perform human-like performance, or at least to complement and enhance human abilities. Because of this capability, it pervades every aspect of the enterprise in the years to come. That is why we believe AI, Automation, and Analytics are central to the success of the enterprise and encompass critical business areas, including data, business processes, the workforce, and risk and reputation.The vision for AI should be guided by innovative thinking - with the long-term objective of enhanced or new, business strategies, and models. The generation of computers known as Quantum Computer (QC) with a quantized technical approach processing unit is opening a new door toward the next generation of AI, which we have introduced to as Super Artificial Intelligence (SAI). Thus, the trend certainly is there, and although these generations of SAI and QC are supposedly are making our life easy to deal with in this fast paste technically growth, yet they are in a serious race with their inventors known as Human. One other adverse effect of AI on humans with it thrive toward SAI is increasing human depression, and some details are presented here in this article as well
13 An Observational Study of DM Complications and their Clinical Outcomes , Doragolla Bhargavi, Gundlapally Prashanthi, Snigda Reddy Pingili and Udayarani
Aim: The purpose of the study is to examine the complications, their associated clinical characteristics and health related quality of life in DM patients Objectives: To evaluate and analyse the clinical outcomes of dabetes mellitus complications. 1. To identify the prevalence of DM complications. 2. To identify about complication percentage (%) in type-1 and type-2 DM. 3. To determine HRQL of patients with diabetes mellitus complications. Methodology: A prospective observational study was carried out at Departments of in and out patients at Gandhi hospital and BBR hospital, for a period of 6 months (July 2017 to December 2017). All the patients who are diagnosed with DM complications were included in this study. Patients between ages of 18 - 90 yrs were considered. Patients with comorbidities of DM were excluded in the study. Results: During the study period, a total of 400 cases of suspected Diabetes complications were recorded from July 2017 to Decem-ber 2017. The total of 400 cases was analyzed, among them the prevalence % was found to be more in Diabetic nephropathy (33%), in which prevalence rate in males was found to be (71.96%) than females (28.03%). According to the age wise distribution, maximum patients belonged to age group 40-60 years. The occurrence of DM complications was identified more in Type-2 DM patients (273) than in Type-1 DM patients (127). Conclusion: The suspected complication cases were analyzed, among them type 2 DM is more predominant than type 1. In type 2 Males are at more risk than females in nephropathy and in males are at more risk than females in DKA. So, 40-60 age group were highly affected with complications. Clinical outcome measures of GRBS levels was found to be more in patients with GRBS levels of 200 - 300 (42.5%), FBS levels was found to be more in patients with FBS levels of 120 - 130 (39.5%), HbA1C levels was found to be more in patients with HbA1C levels of 7.5 - 8.0 (39.5%), BP levels was found to be more in patients with BP levels of stage 2 (46%), lipid levels was found to be more in patients with lipid levels of 50 - 100 (55%).  
14 Intravenous High-Dose and Supplementation of Vitamin C Can Effectively Prevent and Treat COVID-19? , Attapon Cheepsattayakorn1, Ruangrong Cheepsattayakorn and Utoomporn Sittisingh
Coronaviruses and influenza viruses, the pandemic viruses can cause acute respiratory distress syndrome (ARDS) contrib-uting to lethally acute lung injuries (ALI) and death. Activation of nuclear factor erythroid 2 (nfe2)-related factor 2 (nrf2), a major regulator of antioxidant response element (ARE)-driven cytoprotective protein expression plays an critical role in pre-venting cells and tissues from oxidative-stress-induced injury. Both viral and bacterial infections can contribute to cytokine storm that results in increased oxidative stress. Vitamin C is beneficial to critical care management due to its important component of the cellular antioxidant system. High-dose vita-min C has been clinically used for several decades. Intravenous high dose of vitamin C may be applicable to COVID-19 since the prevention and management of oxidative stress could be ad-ministered by large dose of antioxidant. By eating a variety of food, particularly fruits and vegetables, individuals can easily achieve 100 to 200 mg of vitamin C that is proved to be ad-equate to optimize cell and tissue levels for the reduction of the risks of chronic diseases. One medium-size orange contains 70 - 80 mg of vitamin C, one cup (around 100 grams) of broccoli contains 90 mg of vitamin C, and one large red guava contains approximately 120 mg of vitamin C. At least 200 mg of daily vi-tamin C supplementation is effective in improving the duration and severity of the common cold, both in children and adults. Nevertheless, the “prophylactic” dose of vitamin C for disease prevention is controversial.
15 Development and Validation of Visible Spectrophotometric Methods for the Analysis of Etravirine: Application to Tablet Dosage Forms , Murali Dadi1, Indra Sen Singh1 and G Purna Chandra Rao
The present study describes the development and validation of two simple, sensitive, accurate, precise and economical spec-trophotometric methods for the estimation of Etravirine (ETR) in bulk and its tablet dosage forms. These methods have developed based on the diazotization of ETR followed by coupling with alkaline β-naphthol (Method-A) and p-nitro aniline in alkaline medium (Method-B). These methods show a linear relation between absorbance and concentration of ETR in the ranges of 5 - 30 μg/mL (M-A) and 2.5 - 15 μg/mL(M-B) respectively. The Molar absorptive for present methods are 3.685 x 103 (M-A) and 5.614 x 104 (M-B) and LOD, LOQ values are 0.656 μg/mL, 1.990 μg/mL (M-A) and 0.191 μg/mL, 0.578 μg/mL (M-B) respectively. The common excipients in the drug did not interfere in the estimation process and the developed methods are successfully applied to tablet dosage forms of ETR.
16 Molecular Docking Studies; 1,3 Thiazines Derivatives , Khan Sana, Singh Gurdeep and Sainy Jitendra
ome novel derivatives of 1,3-thiazine have been synthesized by the condensation of 2-hydroxy-3-nitro5-chlorochalcones with thiourea and phenylthiourea in ethanol containing aqueous KOH solution. The synthesized ten 1,3 thiazine derivatives were subject-ed to molecular docking studies against E.coli Glucosamine-6 P Synthase in Complex with Fructose-6 P (PDB ID-4 AMV) and Crystal structure of Peptide deformylase from Staphylococcus aureus Complex with Actinonin (PDB ID-1Q1Y) usingMolegro Virtual Docker software. All synthesized compound have been screened for in-vitro evaluation of antimicrobial activities by agar plate techniques. The results indicated that all the synthesized 1,3 thiazine derivatives shows considerable antimicrobial activities on gram negative (E. coli) bacteria This study suggested that 1,3-thiazine derivatives possess more antimicrobial activities on gram negative (E. coli) bacteria than gram positive bacteria (S.aureus).
17 A Case Report on Colistin Induced Myasthenia Gravis , Pulimi Divya Priyanka, Vithya Alhas, Farhan1 and Manoharan, Shankar Prasad, Shobha Rani R H
A 60-year-old Male got admitted to Surgical ward of tertiary care hospital with the complaints of wound debarment on left leg and left thigh abscess since two months and foul smell from 15 days associated with complaints of pain in both lower limbs. He is a known case of Type II DM from 10 years, HTN since one year, CLD, CKD from one and half year and on hemodialysis with oral medications. After adequate preoperative work up, the patient was taken for surgery with high risk and underwent skin grafting and withstood the surgery. The patient culture reported growth of Pseudomonas aeruginosa and on first day IV Colistin 1 Million Units TID, IV Clindamycin 600 mg BD and IV Meropenem 1 gm TID were prescribed. The patient developed Myasthenia gravis and Neurologist confirmed it as Colistin induced and the same was stopped on 13th day. Neostigmine 2.5 mg BD was prescribed and extubated. He was treated with other antibiotics and supportive treatment. Patient improved symptomatically after the withdrawal of Colistin and discharged in a stable condition with multivitamins, Anti-Hypertensives and Anti-Diabetic medications.
18 A Minireview on Pandemic Novel COVID-19 , V Anilkumar
Human history is observing a very strange time fighting an invisible enemy, the novel COVID-19 coronavirus. initially observed in the Wuhan province of China, now vastly spreading around the world. The Pandemic which COVID-19 has made on the Globe needs no depiction. The virus has been accounted for to be affecting the lungs and related respiratory tracts promoting harm of the alveoli. It has been accounted the respiratory sickness is the prevailing Clinical indication of COVID-19. This review article discussed for an easily understanding of the causes, different type of Human viruses regarded of Coronavirus, clinical diagnosis of RT-PCR, Primary prevention and control of the virus. Therefore, this review article main theme is focusing on more research work to be carried out to provide more reliable and valid effect to control and mange public emergency in both acute and chronic conditions of coronavirus.
19 Cosmetics and Beauty Products Review , Heyam Saad Ali
The word “Cosmetics” is known to human race since ages. At the same time, desire to look good and attractive for every individual also can be identified as the psychological need having been given the upper place in hierarchy for ages. However, it will be relevant to understand the exact meaning of the word „cosmetic‟ from various sources at the outset.
20 A Comprehensive Review in Parenteral Formulations , Heyam Saad Ali
Parenteral Formulations are sterile, pyrogen-free, administered by injection through skin layers. This review highlights all the as-pects regarding parenteral products advantages, disadvantages, routes of administration, additives, preparation, types of containers and quality control tests for evaluation.
21 Formulation and Evalution of Telmisartan Solid Dispersion of Encapsulation Using Different Polymer , Kabita Banik and K Yashasree
The aim of the present study was to improve the solubility and dissolution rate of a poorly water soluble drug, telmisartan by solid dispersion technique. The objective of the study is to prepare telmisartan solid dispersion and encapsulation using different polymers to achieve the enhanced solubility and to determine the Kinetic Modeling of Drug Release and Stability studies. Telmisartan has PH dependent solubility. Due to this reason only the % release for the prepared solid dispersions was higher in PH 4.5 acetate buffer when compared with other mediums. Based on mathematical data revealed from models, it was concluded that the release data was best fitted with First order kinetics. Stability studies showed that there were no significant changes in physical and chemical properties of capsule of formulation after 3 months.
22 An Assessment of Quality of Life of Hypertensive Patients Visiting a Hospital in Warri, Nigeria , Rita O Akonoghrere, Ogheneovo C Aghoja1, Omobamidele B Betiku, Zipporah E Adje and Azuka C Oparah
Purpose: Health related quality of life is a multi-dimensional concept that includes domains related to the physical, mental, emotional and social functioning. It evaluates both the positive and negative aspect of life. This can be evaluated using various instruments so as to know areas to improve therapy. This study was done to assess the quality of life of a group of hypertensive patients, and to determine predictors of their quality of life. Method: This was a descriptive cross- sectional study designed to assess the quality of life of hypertensive patients. The sf-12 questionnaire was used to assess Quality of Life in ambulatory patients. Data was obtained from patients visiting two facilities in Delta state, Nigeria. Results: The total sample size used was 122 respondents of which 72 were males (58.5%). The mean Physical Component Summary (PCS) of quality of life was 47 ± 7.5; while the mean Mental Component Summary (MCS) of quality of life was 46.7 ± 9.2. The mean systolic blood pressure was 139.6mmHg ± 19.1 while the mean diastolic blood pressure was 82.8mmHg ± 13.3. The Beta value obtained from all the analysis were > 0.05, hence there were no significant predictors of quality of life. Conclusion: Quality of life was generally low and below the Norm of 50% according to the US standard. The physical component scale however was the most affected. Neither the clinical status nor the socio-demographics of the patients were predictors of their quality of life.
23 Antioxidant Potential of Vernonia occephala , Usman M, Aliyu AB, Momoh MA and Faruq UZ
In this study, antioxidant activities of ethanolic extracts, ethyl acetate, n-butanol and chloroform fraction of Vernonia oocephalawere evaluated using DPPH free radical scavenging assay, total phenolic contents, reducing power assay and total antioxidant capac-ity. The free radical scavenging activity expressed as percentage antioxidant activity was highest in ethyl acetate fraction of (EC50 = 20.0 ± 0.005 μg/ml). The total phenolic content was highest in ethyl acetate fraction (106.0 ± 0.003 mg/g GAE). Also, the ethyl acetate fraction exhibited the highest total antioxidant capacity (100 mg g-1 ascorbic acid equivalent). The chloroform fraction exhibited the highest reducing power at all concentrations. There is no significant difference between the standard and the sample (P ≤ 0.05). The results of this study have shown that Vernonia oocephala contains antioxidant chemical substances and therefore can be considered as a good source of natural antioxidants for medicinal uses.
24 Coronavirus Disease Pandemia 2019: Growth of Epidemic Dangers , VO Shapovalova, SI Zbrozhek, EV Suprun, VV Shapovalov and VV Shapovalov
The article is devoted to the problem of the emergence in 2019 of diseases caused by the new coronavirus (“coronavirus disease 2019”), which have already gone down in history as an emergency of international importance. The most common clinical mani-festation of a new infection is pneumonia, and in a significant proportion of patients - respiratory distress syndrome. A virological, epidemiological and clinical study of severe acute respiratory syndrome, Middle East respiratory syndrome and the outbreak of acute respiratory diseasein 2019-2020 was compared in Wuhan (Hubei, People's Republic of China, China). Analysis of the scientific literature data on the coronavirus disease pandemic 2019 based on the systematization, synthesis and comparison of documentary data regarding: historical aspects of the study of coronaviruses; severe acute respiratory syndrome; Middle Eastern Respiratory Syndrome; SARS-CoV-2 virus disease COVID-19; comparative characteristics of SARS/MERS/COVID-19. When conducting the study, we used the current legislative, regulatory and instructive documents, Internet resources. They used regulatory, documentary, bib-liographic, comparative and graphical methods of analysis. The article presents the results of a comparison of the virological, epide-miological and clinical studies of severe acute respiratory syndrome, Middle East respiratory syndrome and the outbreak of acute respiratory disease in 2019-2020 years in Wuhan (Hubei, People's Republic of China, China). Established that the etiological agent of COVID-19 is coronavirus, phylogenetically close to the causative agent of SARS (SARS-related human CoV virus) and related corona-viruses isolated from bats (SARS-related bat CoV viruses). The data obtained are the basis for the need to continue further research and reviews of the coronavirus pandemic in the direction of finding methods for effective treatment of patients with this pathology.
25 In Depth Investigation of Quantitative Analytical and Bioanalytical Techniques of Paroxetine in Different Matrices: A Review , Satchitkrishna Radharapu, Dhara Patel and Dhananjay Meshram
Analytical method helps in ensuring the safety and efficacy of drugs in different matrices by determining the quantity and quality of Drug. A detailed extensive literature survey is one of the most essential requirements for all focused research activities. Paroxetine is a selective serotonin reuptake inhibitor (SSRI). It is used to treat several diseases including major depressive disorder, obsessive-compulsive disorder, social anxiety disorder, panic disorder, posttraumatic stress disorder, generalized anxiety disorder, and premenstrual dysphoric disorder. Sincere effort has been made in the present review to collate all the relevant literature published in various pharmaceutical journals for determination of Paroxetine in different matrices both individually and in combination with other drugs. In this article main emphasis is given on the various techniques which are used for the estimation of the Paroxetine from various Pharmaceutical dosage forms or in biological matrices. The review highlights the basic as well as advanced techniques performed for estimating Paroxetine. Among different methods, HPLC and UV-Visible spectrophotometry are the most widely used techniques applied by the researchers. Detailed validation parameters are also given for the methods, which helps the researchers to select an analytical technique based on the information sought.