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Acta Scientific Neurology

Journal Papers (16) Details Call for Paper Manuscript submission Publication Ethics Contact Authors' Guide Line
1 Effect of Renal Complications on Brain - An Overview , Shalini K Mehta and Sivakumar JT Gowder
The association between chronic kidney disease (CKD) and cardiovascular disease has been extensively studied but, at the same time, little information has been available on the relationship between kidney and brain. In this manuscript, we have evaluated the recent updates on the relation between CKD and neurological disorders based on literature review and survey. A wide spectrum of neurological disturbances and behavioral changes such as fatigue, head ache, sensory clouding, vision impairment, seizures, delirium and coma can be observed in patients with renal complications [1-4]
2 Optic Neuritis and Hypophysitis: Partial Remission after Pulse Therapy , Isabela Morales Cozeto, Lívia Norcia Zenerato, Letícia Alarcão Max-ta, Ricardo Baer Filho, Érico Paulo Heilbrun, Márcio Luis Duarte and Lucas Ribeiro dos Santos
Lymphocytic or autoimmune hypophysitis (AH) is a rare disorder characterized by inflammation of the pituitary gland. There is no consensus on treatment, but may include corticosteroid therapy and decompression surgery. Optic neuritis (ON) is an inflammati-on of the optic nerve, both of unknown etiology and autoimmune hypothesis. The association of pathologies is rare, with few reports in the literature. The diagnosis of ON is clinical and treatment with high dose corticosteroids. A case initially diagnosed as ON with pituitary macroadenoma is described: 55-year-old woman with sudden bilateral visual loss associated with nausea, vomiting, diarr-hea and hypotension, MRI with pituitary expansive lesion with optic chiasm compression and laboratory tests showing thyrotrophic, corticotrophic and gonadotropic axes deficiencies, associated with mild hyperprolactinemia. Methylprednisolone pulse therapy was performed for ON treatment. Patient presented improvement of visual acuity, decreased pituitary volume and recovery of cortico-trophic axis, raising the hypothesis of AH. The case demonstrates the importance of careful neuro-ophthalmologic and radiographic evaluation of patients with pituitary adenoma and visual loss. NO and AH should be considered in the differential diagnosis as this may prevent unnecessary invasive procedures.
3 Impact of Psycho-Social Intervention in Patient with GBS in Neurological Rehabilitation Set Up: A Case Report , Arun M and BP Nirmala
The current case report describes the psycho-social assessment carried out with a person diagnosed with Guillain-Barre syndro-me. Psycho-social assessment sheet which is developed for assessing psycho-social factors of patients with neurological disorder and hospital anxiety and depression scale has been used in the case report. This report also focuses on the caregiver’s issues and the associated interventions. The common psycho-social intervention which was used in this case has alleviated patient’s emotional distress and helped her go through rehabilitation process effectively. Findings of this case study support the fact that medical mana-gement complimented with psychosocial intervention could help the patient and family members deal with social and psychological dysfunctions effectively.
4 The Psychology of Patients Infected with COVID 19 in Tunisia during the Treatment Period , Kahna Mohamed, Cherni Bochra and Baaouni Zaineb
The COVID-19 still causes anxiety and apprehension among many patients today, which can lead to a refusal of care or difficult working conditions. It, therefore, appears prerequisite to set up conditioning and relaxation methods for patients and caregivers to optimize care and working conditions. In this regard, we assess the psychological levels of patients in their forties to detect the fac-tors in order to facilitate the treatment.
5 Coronavirus - The New Generation Influenza Psychiovirus , Vahram R Sargsyan
The paper presents a new scientific approach for interpreting the mechanisms of functioning of the influenza virus in nature. New biological theories are discussed - viral theories, on the basis of which the coronavirus known to everyone since 2019 is considered as a psycho-influenza virus. More details are given - the viral theory of biocommunication and the viral theory of signal transduction. In conclusion, modern scientific methods of protection against infectious diseases are proposed.
6 Enhancement of Function of the Prefrontal Cortex to Improve Symptoms of Schizophrenia , Prajjita Sarma Bardoloi
Schizophrenia is a chronic psychotic illness with multifactorial etiology that manifests with a constellation of positive, negative, affective and cognitive symptoms [1]. As we are learning more about the neurobiology of schizophrenia, the role of the prefrontal cortex (PFC) in schizophrenia has become more evident. While various medications are available to treat psychotic symptoms in schizophrenia, treatment of cognitive functions, residual symptoms and comorbid disorders is still a substantial challenge. Here we present a case of a young male who suffers from schizophrenia, with a previous diagnosis of ADHD and substance abuse, who showed remarkable improvement following treatment with the alpha-2A adrenergic agonist guanfacine, likely related to enhanced PFC function
7 Mental Health of Healthcare Personnel during Quarantine for Infectious Epidemic--Real-time Data , Uriel Halbreich and Fanqiang Meng
Background: The 2020 Coronavirus (COVID-19) pandemic has been causing significant fear and anxiety among the general public and demonstrate insufficient preparedness of Healthcare systems. It shed light on front-line Healthcare-personnel who should func-tion and treat others while they share the same stressful situations.Objective: To provide actual real-time data on mood and mental symptoms of Healthcare personnel in quarantined wards during the Chinese-SARS epidemic, in order to support procedures for functioning of personnel during current and future epidemics.Setting, Participants and Measurements: Cross-sectional Study was conducted during the acute exacerbation of the SARS epide-mic at quarantined wards by nurses who were embedded and quarantined with the patients. Mood and perceptions of Healthca-re-personnel infected (n = 55) and not infected (n = 149) with SARS, as well as those during quarantine “rehabilitation” (n = 62) were compared to SARS patients (n = 96), healthy quarantined students (n = 55) and healthy non-quarantined controls (n = 52).Structured interviews were conducted with the Beck Depression Inventory (BDI), Spielberger’s State-Trait inventory, symptoms Checklist-90 (SCL-90) and a situation-specific questionnaire.Results: Healthcare-personnel -- infected and not-infected, suffered as much mood, anxiety and other stress-induced symptoms as their SARS patients. Strictly enforced quarantine amplified personnel’s frustration, mental symptoms and mistrust in authorities.Limitations: Data was collected when many patients were assisted by respirators, some could not be included.Conclusion: During acute epidemics front-line Healthcare-Personnel are exposed to same and even more extreme situations as their patients. Their emotional state under tumultuous situations should be of concern.Implications: Mental well-being procedures and enhancement of Mental resilience of Healthcare teams should be an integral com-ponent of their preparedness for future disasters
8 Takotsubo Cardiomyopathy Resulting from Transient Global Amnesia Following a Sexual Encounter , Kamalpreet Dhaliwal, Sonia Randhawa, Nabihah Kabir, Yadwinder Sidhu, Harsimran Singh, Shawn Banash, Muhammed Janjua and Vib-hav Bansal
Background: Transient global amnesia (TGA) is a neurological condition described as acute onset anterograde amnesia that resolves within 24 hours. TGA is often associated with migraine history, psycho-physical stress, and cardiovascular risk factors. Takotsubo Cardiomyopathy (TTC), also known as Broken Heart Syndrome, is a reversible, stress-induced weakening of the left ventricle (LV) resulting in cardiomyopathy. Concurrent occurrence of the two syndromes have rarely been reported. To date, there have been 10 documented concurrent TGA and TTC cases, all unrelated to sexual triggers. Here we report the first patient with simultaneous TGA and TTC following a sexual encounter.Insights and Aim: Summarize a case and its associated factors to establish awareness of a possible causal relationship between TGA and TTC following a sexual encounter as a precipitating factor. Case Report: A 66 year-old woman presented to the emergency department with sudden onset confusion and forgetfulness wit-nessed by the patient’s husband immediately after sexual intercourse.Neurologic exam on admission revealed short-term memory deficits, resulting in repeated questions of similar nature regarding the peri-ictal period. Lab results revealed an elevated High Sensitivity Troponin-T of 51 ng/L (normal, < 14 ng/L); all other pertinent labs were within normal limits. The patient’s neurological manifestations of amnesia resolved 14 hours after the time of presentation. Conclusion: Although TGA is considered a primary neurologic disorder, it is important to recognize a possible relationship between TGA and TTC in order to manage the cardiac complications that may arise from TTC
9 The Transcranial Direct Current Stimulation (tDCS) and Biofeedback (BFB) as a Mixed Methods in Reducing Symptoms of Migraine , Mohammadjavad Hoseinpourfard and Masoumeh Shajarian.
Migraines may be induced by triggers such as fatigue, certain foods, weather, and so on. Of-course some patients with migraine report other experiencing triggers include dietary and sleep disor-ders. Many of symptoms pertaining to the migraine may start, up to 24 hours after a trigger and continue for 72 hours. In addition, the psycho-physiological aspects could consider as other important triggers.
10 Class-I MHC-Restricted T-Cell Associated Molecule (CRTAM) Expression in Cerebellum. , Esther López-Bayghen, Karla Pérez-Toledo, Leticia Ramírez- Martínez, Jacqueline Robledo,Vianney Ortiz and Arturo Ortega.
The class-I MHC-restricted T-cell associated molecule (CRTAM), an activation molecule expressed in activated Natural Killer cells (NKT) and CD8+ T cells, is highly expressed in the cerebellar cortex, both in neurons and glial cells. During cerebellar development, granule cell migration over Bergmann glia cells depends on neuronal/glia glutamatergic signaling, suggesting a regulated cell-cell in-teraction process, opening the possibility of CTRAM and Nectin-like 2 involvement. Through the use of the well-established model of chicken cerebellar Bergmann glial cells and a wound/healing assay, we describe herein that glutamate represses CRTAM expression, enhancing migration. These results reveal an unexpected function of CTRAM in the cerebellum.
11 Corona Virus (COVID-19): A Brief Status in India about its Transmission and Precaution. , Abhishek Jha, Deepak kumar Mishra, Deepika Sharma  and Suvercha Arya.
Coronaviruses were first discovered in the 1930s when an acute respiratory infection of domesticated chickens was shown to be caused by infectious bronchitis virus (IBV). Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CO-V-2), was first reported in Wuhan, Hubei province, China has now rapidly spread over 200 countries. Rapid worldwide spread of Coronavirus Disease 2019 (COVID-19) has resulted in a global pandemic. Current Scenario of India is also not however very good and facing a high risk despite a continuous lockdown from 22nd March - 17th May 2020. However, the lockdown is again increased from 18th May - 31st May 2020.
12 External Ventricular Drains: An Overview of Indications, Technique, and Complications. , Anudeep Yekula,  Aditya Mittal, Varun Sagi  and Mihir Gupta.
External ventricular drains (EVDs or ventriculostomies) are frequently required for acute management of intracranial hyper-tension and monitoring intracranial pressure. Patients with ventriculostomies are frequently co-managed by multiple specialists including neurologists, neuro-intensivists, trauma specialists, emergency department physicians and neurosurgeons. We provide background on the indications, placement technique, troubleshooting and complications related to this procedure. We also discuss emerging best practices for preventing complications such as ventriculostomy-related infection. We conclude with considerations regarding ventriculostomy removal and areas of ongoing study. This review serves as a primer that may facilitate collaborative care between diverse allied providers.
13 Need for Antimicrobial Agents in Daily Applications in Hygiene and Disinfection: An Opinion. , Shimon Shatzmiller.
The hygienic situation in hospitals and other health facilities have become a source of sickness that is killing thousands all over the place, and in Israel as well. A similar situation is in agricultural land. Since the ban on the use of methyl-bromide for soil disinfec-tion, agricultural products can be infected with species of dead causing microbes, germs, and viruses. Imitation of natural materials isolated from amphibians and reptiles (crocodiles) can bring relief. These natural substances act on the bacteria in a way that does not cause the resistance of the microbes. Natural like synthetic imitators can be used, which can be produced in large quantities and low economic requirements and eradicate the pathogens in the soil and hospitals.  
14 Simple Strategies for Brain Health. , Seyedeh Nasim Habibzadeh.
The brain is a major organ in human body that is made up of a large nervous system of nerve tissues which process the sensory information and controls the thoughts, memory and speech. The brain also governs the movement of the limbs and the function of many other organs within the body. The brain is very highly sensitive organ which can harm easily. Any bad news, unexpected shocks and daily pressures can affect the brain functions. However, the servers kind of negative aforementioned stresses can cause the brain waves or vibrations and even any low level of stresses can induce the brain unwanted waves afterwards. In this regards, stress management would account for a good strategy to improve the brain health. Avoiding of being in stressful environments and performing some gentle exercise like walking and listening to the music can be very beneficial approaches to protect the brain and its functionality in time.
15 Love, Bonding Phenomenon, and the Healthy Narcissism. , Ronnie Solan  and Anat Ben-Artsy.
It is common psychoanalytic knowledge that the influence deriving from childhood experiences carries well on into adulthood. This article’s main objective is to disclose the survival motive behind the influence of childhood experiences throughout life. The survival motive seems to relate to the Healthy Narcissism Processing [1-3], a process metaphorically scrutinized to an Emotional immune system. Memory traces of childhood experiences, such as intimacy with the object or Separation Anxiety, etc., reverberate all along life through the processing of Healthy Narcissism. Accordingly, the sense of the Familiar Self may be preserved, immunized and assisted. Likewise, the “Me” and its belongings (like its objects and love relations) are recognized as familiar, stimulated to be restored, revived and recharged in present experiences according to past involvements. Re-finding the familiar senses in present events, according to the models of past experiences, facilitates adaptation to daily relationships and to almost familiar occurrences.
16 Critical Evaluation of Physical Exercise on Brain Structure and Function. , Mahsa R M Mansouri and Sivakumar J T Gowder.
Physical activity or physical exercise act against the sedentary lifestyle-induced health matters such as cognitive decline or neu-rodegenerative diseases. Physical exercise and physical activity is important for people of all age groups that not only could enhance mental capacity and social interactions development of pre-school aged children, but also could maintain and ameliorate muscle strengthening and health condition such as high blood pressure of old adults. Physical exercise also, acts as gene modulator which develops brain function due to structural and functional changes such as neurogenesis, glycogenesis, brain volumes, white matter integrity, neurotrophies levels and or cognitive performance.