Chronicles of Pharmaceutical Science
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Design and Evaluation of Cefixime Fast Dissolving Tablets Using Super Disintegrating Agents
V L Narasaiah*, G Saravanan, S M Shahidulla, M Praveen Kumar, L Gopala Krishna and K Elesu Babu
The aim of the present investigation was to formulate fast dissolving tablets of Cefixime by wet granulation using super disintegrants such as crospovidone, croscarmellose sodium, and sodium starch glycolate. The prepared tablets were evaluated for post compressional parameters like hardness, friability, weight variation, in-vitro disintegration time, in-vitro dispersion time, wetting time, in-vitro drug release studies. The drug-excipient interaction was studied by Fourier transform infrared spectroscopy (FTIR) studies. No chemical interaction between drug and excipients was confirmed by FTIR studies. Amongst all formulations, formulation F12 prepared by 24 mg of crospovidone showed less disintegrating time of 18.4 sec and faster dissolution. Enhancement of oral Bioavailability of cefixime can be increased by formulating it as a Fast Dissolving Tablet using crospovidone as super disintegrating agent.