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Advances in Applied NanoBio-Technologies (AANBT)

Journal Papers (22) Details Call for Paper Manuscript submission Publication Ethics Contact Authors' Guide Line
1 Surface Modification of Nano-Hydroxyapatite by Coating Stearic Acid , M. Yousefi1*, N. Modghan2, M.H. Ebrahimzadeh2   1 Department of Orthopaedic Surgery, Mashhad University of Medical Sciences, Mashhad, Iran 2 Department of Materials Science and Engineering, Faculty of Engineering, Ferdowsi University of Mashhad, Mashhad, Iran
Todays, researchers are challenging with manufacturing polymeric nanocomposites reinforced with ceramic particles due to two inherent properties of ceramic reinforcement particles, particle agglomeration and incompatibility between hydrophilic ceramic particles and hydrophobic polymeric matrix. So in this study, we used nano-Hydroxyapatite (n-HA) as ceramic material and Stearic acid as amphiphilic material for coating n-HA, hydroxysteric acid (SA) surfactant was used for surface coating particles between the hydrophilic HA powders and the hydrophobic polymers. The surface modification and effect of this method were evaluated by by Fourier transformation infrared (FTIR), x-ray diffractometer (XRD), thermal gravimetric analysis (TGA) and Scanning electron microscopy (SEM). The result of FTIR showed that n-HA surfaces were modified successfully and the modification method had the proper grafting amount according to TGA due to this method of modification will be proper for coating reinforcement particles in polymeric matrix.                                                                                          Keywords: Hydroxyapatite, Stearic acid, Hydrophilic ceramic, Amphiphilic, Stearic acid
2 The Importance of Silver Nanoparticles in Human Life , Sh.Ahmadi*1   1 Department of Science, Payame Noor University (PNU), Tehran, Iran
Abstract      One of the nanomaterials which having an early impact in health care product is nano-silver. Silver has been used for the treatment of medical ailments for over 100 years due to its natural antibacterial and antifungal properties. The nano silver particles typically measure 25nm. They have extremely large relatively surface area, increasing their contact with bacteria or fungi, and vastly improving its bactericidal and fungicidal effectiveness. The nano silver when in contact with bacteria and fungus will adversely affect cellular metabolism and inhibit cell growth. The nano silver suppresses respiration, basal metabolism of electron transfer system, and transport of substrate in the microbial cell membrane. The nano silver inhibits multiplication and growth of those bacteria and fungi which cause infection, odor, itchiness and sores. Nano Silver can be applied to range of other healthcare products such as dressings for burns, scald, skin donor and recipient sites; acne and cavity wounds; and female hygiene products – panty liners, sanitary towels and pants.                                                                                Keywords: Nanotechnology, Nano Silver, bactericidal, fungicidal, Silver
3 Investigation Preliminary antimicrobial and anticancer properties:  on Topic Rubia tinctorum plant by using Polydimethylsiloxane (CAR/PDMS) , A.Hoseinzadeh1, Y.Sadeghipour1, G.Behbudi2*   1 Department of Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran 2 Department of Chemical Engineering, University of Mohaghegh Ardabili, Ardabil, Iran
In this study, the antioxidant content in Rubia tinctorum was investigated. The extraction of essences is sensitive to operational conditions. Therefore, the effect of different extraction techniques by using HS -SPME fiber assembly Carboxen/​Polydimethylsiloxane (CAR/PDMS), on the quality of essence oil composition was inspected and the composition of the final product was recognized using gas chromatography and mass spectroscopy.Essential Rubia tinctorum is widely used in pharmaceutical, sanitary, cosmetic, agriculture and food industries for their bactericidal, virucidal, fungicidal, antiparasitical and insecticidal properties. Their anticancer activity is well documented. This review is focused on the activity of essential Rubia tinctorum and their components on various types of Blood cancer cells. The chemical composition of the essential Rubia tinctorum from was analyzed by GC-MS. The main constituents were. Ocimene , Sabinene hydrate acetate, Bornyl acetate, Thymol , Methyl isoeugenol ,isoelemicin, Asarone, Neophytadiene. The cytotoxic effect of essential and extracts Rubia tinctorum were analyzed, the results showed that the substance. Good resistance against the toxicity of cell lines is shown MOLT4.   Keywords: Antioxidants, Gas chromatography, Rubia tinctorum, Blood cancer cells.
4 Modification and Improvement of  Fe3O4-Embedded Poly(thiophene) Core/Shell Nanoparticles for Cadmium Removal by Cloud Point Extraction , Y. Sadeghipour1, F.Mojoudi2, G.Behbudi3*   1 Department of Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran 2 Department of Fisheries and Environmental Sciences, University of Tehran, Tehran, Iran 3 Department of Chemical Engineering, University of Mohaghegh Ardabili, Ardabil, Iran
Cloud Point Extraction (CPE) as an effective method for pre-concentration and separation of cadmium from aqueous solution is widely utilized. This study involves a surfactant mediated CPE procedure in order to remove cadmium from waste water using Polythiophene nanoparticle and Triton X- 100 as a non – ionic surfactant. Polythiophene – coated iron nanoparticles was successfully synthesized with novel method and as a super magnetic nano-particles (MNPs) for cadmium removal from aqueous solution was evaluated. Polythophene nano-particles emulsifying method have been synthesized and fabricated. Fabricated nano-particle was characterized by Fourier-transform infrared spectroscopy (FTIR), and analysed transmission electron microscopy (SEM). Effects of pH, buffer volume, extraction time, temperature, amount of nano-particle were essentially investigated. To reach in optimum conditions, related experiments were replicated and accomplished as well. For removal of cadmium by CPE approach the optimization conditions were gained at pH = 7 , volume of buffer acid 1.5 millilitre , electrolyte concentration (NaCl) of 10 -3  mole L-1  , Trinton concentration 5 %, cloud point temperature 80 0 C , extraction time 40 minutes, and 5 mg of modified polythiophene nano-particle. The calibration graph was liner with a correlation coefficient of 0. 9984 and represents appropriate liner correlation with an amount and concentration. The results revealed that 5 gram of modified nanoparticle can significantly increase the efficiency of cadmium removal.                                                                                          Keywords: Polythiophene, Iron nanoparticles, Cadmium removal, Cloud Point Extraction
5 Phenol Novalac Epoxy-modified unsaturated polyester hybrid networks by Silica Nanoparticles/ and Cross linking with Silane Compounds , Sh.Ahmadi*1 1 Department of Science, Payame Noor University (PNU), Tehran, Iran
In this study epoxy phenol novalac resin which consists of silica nanoparticles and unsaturated polyester resin linked to the Silane and cross linking to that structure and also parameters affecting the processes involved have been evaluated. Cross linking in phenol novalac epoxy resins effects on many properties such as thermal, electrical, mechanical and chemical attributes especially in elevated temperatures. Silane cross-linking’s in phenol novalac epoxy resin with respect to other methods like proxiding, irradiation and utilization of Azo compounds, looks to be a very simple and low cost route, which makes it very encouraging for various industries. Unsaturated polyester resin is compatible with phenol novalac epoxy resin and also creates some cross-linking and as far as Trimethoxy Silane is added to the mentioned resin, its thermal, physical and mechanical properties are optimized. In this literature impact, tension, glass transition temperature, humidity absorption, FTIR and Scanning electron microscopy (SEM) tests were done and the results revealed that as the cross-linking occurs, tension in rupture region increases. This increase is more common at elevated temperatures. The growth in content of silica nanoparticles leads to a drop in water permeability of phenol novalac epoxy resin nanocomposite which contains unsaturated polyester resin. Keywords: Phenol Novalac Epoxy resin, Trimethoxy Silanee, Unsaturated Polyester resin
6 Mini review of polysaccharide nanoparticles and drug delivery process , Farzad Raeisi 1*, Elham Raeisi 1 1 Department of Chemical Engineering, University of Mohaghegh Ardabili (UMA), Ardabil, Iran.
Abstract      In recent years, according to research, the role of polysaccharides as drug carriers has attracted much attention. Polysaccharide nanoparticles have been considered as vesicles of various pharmaceutical agents due to the existence of special multifunctional groups in addition to physicochemical properties such as biocompatibility and biodegradation. The presence of groups with different applications on the main constituent structure of the polysaccharide allows easy chemical or biochemical modification for the synthesis of polysaccharide-based nanoparticles with different structures. Nanogels with polysaccharide base and structure have high water content, large surface area for polyvalent biological binding, adjustable size and internal network for combining different drugs. These special properties make it possible to use polysaccharide-based nanogels in drug delivery systems. Keywords: Polysaccharide, Nanoparticles, Drug delivery
7 Recent advances in gene delivery using nanostructures and future prospects , S.N.Abootalebi1,2*, E.Shorafa2   1 Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. 2 Division of Pediatric Intensive Critical Care, Department of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. 
Gene therapy has attracted much attention as an encouraging solution to treat a wide range of diseases rather than rare hereditary and single-gene disorders. For this purpose, nucleic acids must be delivered to human target cells. This article reviews the history, key issues, recent advances, and future of gene therapy using nanostructures. Some intracellular and extracellular barriers need to be removed. Today, a wide range of nano-vectors vectors have been developed. Several vectors based on nanostructures have been developed and used for the successful treatment of some inherited diseases, immunodeficiency, ocular and cancer. Viral vectors are suitable for gene therapy for diseases that require long-term gene expression. Although non-viral vectors are less effective than viruses, they are more specific, have less immunogenicity, and are capable of transmitting longer genes. Overall, recent advances in various gene therapy strategies have been able to meet some of the expectations of gene therapy for years, and have raised many hopes for further success. Gene therapy seems to be the ultimate solution of the present century to treat many human diseases. Keywords: Gene therapy, Viral Vectors, Nanostructures, Cancer
8 Graphene Oxide as a Docking Station for Modern Drug Delivery System by Ulva lactuca species study its antimicrobial, anti-fungal and anti-Blood cancer activity , M.shokripour1*, S.Gerayemi2, F.Raeisi3   1Department of pathology, school of Medicine, Shiraz University of medical sciences, Shiraz, Iran 2Zeinabie Hospital, Shiraz, Iran 3Department of Chemical Engineering, University of Mohaghegh Ardabili (UMA), Ardabil, Iran
In this study, employing modified Hummers method coupled with a multi-stage manufacturing procedure, graphene oxide (GO) decorated with Ulva lactuca species GOU at different weight ratios was synthesized. Although Ulva lactuca species treatment with graphene oxide tablets gave a faster release in an acidic medium compared with the commercial product (Ulva lactuca species), the cumulative amount of released drugs of the optimum formulation was found to be almost the same as that of the commercial product at the end of different amounts (h). Treatment by graphene oxid matrix tablet formulations can deliver the drug to the small and large intestine. Thus, the - graphene oxid treatment by Ulva lactuca species may be a promising system for the treatment of Crohn’s disease involving both the ileum and large intestine. The best way to approach this problem is to utilize slow release drugs. In this research, the release of the GOU drug from a graphene oxide base has been investigated. The amount of Ulva lactuca species absorption and then, its release by graphene oxide were studied. XRD, EDAX, MAP, PSA, FT-IR and SEM techniques were used in different steps in order to confirm the experimentations validity. Also MTT test was done to investigate the cytotoxicity of the new nanodrug on the large bowel cells. In this research, acidity level impact, drug density PH, mixing time and the optimum amount of absorbent in absorbing graphene oxide by Ulva lactuca species, and also the anti-fungal and anti-bacterial effect was studied. Keywords: Graphene oxide, Anti-fungal, Anti-bacterial, Ulva lactuca species.
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10 Mini review of Graphene Oxide for medical detection and applications , G.Behbudi*1 1 Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Graphene, has single layer of carbon atoms with unrivaled physicochemical attributes (e.g. ease of functionalization, remarkable biocompatibility, unparalleled thermal conductivity, strong mechanical strength, excellent electrical conductivity and high surface area) has obtained increasing consideration in biomedical, chemical and physical fields. Graphene oxide (GO) is one of the most applicable materials which applied in different applications such as biomedicine, electronics, photocatalysis, sensors and in energy storage (batteries and supercapacitors). Graphene based Materials such as graphene oxide and reduced graphene oxide have a high applicable potential in the medical applications. GO lonely and its improved form with several compounds (composite formation, immobilization of nanoparticles and surface functionalization) also demonstrate as a multifunctional volunteer for medical biotechnology. In this work, investigated the methods of synthesis graphene oxide and reduced graphene oxide (rGO) and their applications in detection of medical fields. In particular, graphene based biosensors for small biomolecules detection, drug delivery, cancer therapy and biosensores have been summarized. Keywords: Graphene oxide- Reduced graphene oxide- Medical detection- Medical applications.
11 High-density polyethylene surface modification for the attachment of Eggshell and Oak Bark Nanoparticles , N.Banaei1, Sh.Ahmadi*2 1 Department of Polymer Engineering, Yazd Branch, Islamic Azad University, Yazd, Iran.  2 Department of Science, Payame Noor University (PNU), Tehran, Iran
Growing production speed of plastics in municipal solid wastes, industrial wastes of petrochemical complexes and related industries are giving rise to environmental, health and economic problems. Abundance sources of agricultural wastes such as rice husk, bagasse, palm fiber, straw, canola and sawdust having limited practical applications are mostly not recycled and most of them discarded or burnt. By collecting these wastes and processing them we are able to produce products having added-value and consequently reduce environmental pollutions. In this project a combination of rice husk and chitosan nanoparticles were combined and formed as a biopolymer. HDPE and also extrusion in a two-screw extruder are used. After producing the composite, physical and mechanical properties of the composite were studied. Analyzing results showed that 36 wt% rice husk has the maximum tensile strength and similarly by reducing the percentage of rice husk and increasing the percentage of chitosan nanoparticles the tensile strength lowered strongly because rice bran have silica compounds too and reducing the percentage of rice husk make tensile strength lowered , also flexural modulus is increased by increasing percentage rice husk but in samples that nanoparticles were increased and rice husk was decreased, flexural modulus decreased too and flexural strength. Keywords: Heavy poly ethylene, eggshell nanoparticles, Oak bark, morphology.
12 Production of calcium silicate Nano-biocomposite and modeling of its flexural and compressive strength with statistics method , Kh.Yousefi1*, H.Danesh Manesh1 1 Department of Materials Science and Engineering, School of Engineering, Shiraz University, Shiraz, Iran.
Nano Fast Cement (NFC) is a nanocomposite with a short setting time for repairing root teeth canals as an alternative to Mineral Trioxide Aggregate. The downside of this new tooth restorative material is the poor workability and low compressive strength. In this study, polyvinyl alcohol (PVA), colloidal nano-silica, and hydroxyapatite nanoparticles were added to NFC to improve its physical, mechanical, and biocompatibility properties of NFC. The effects of the three additives on strength were determined. Experiments were designed based on the Taguchi method. The optimum contents of the three additives for the highest compressive strength, flexural strength were also obtained. The results showed that the most effective factor on the mechanical (compressive & flexural strength) properties of NFC is polyvinyl alcohol. Based on the Taguchi method, the optimal (highest value) of the mechanical property is obtained for PVA, nano-silica, and nano-hydroxyapatite contents of 6, 0.5, 0 Wt.%. Keywords: Nano Fast Cement (NFC), Hydroxyapatite Nanoparticles, colloidal nano-silica, Polyvinyl Alcohol, Optimization.
13 Thermo Mechanical behaviour of Phenol Novolac Resin and Unsaturated Polyester Toughened Epoxy using nano Bentonite and Silica Nanoparticles , MR.Jamshidi1*, Sh.Ahmadi2 1 Department of Chemical Engineering, Islamic Azad University, Shiraz Branch, Shiraz, Iran. 2 Department of Science, Payame Noor University (PNU), Tehran, Iran.
Phenol novolac epoxy resin is a polymer matter which its properties can be modified for industrial needs. In this research, nanocomposites of phenol novolac epoxy resin and unsaturated polyester are made nano Bentonite and silica nanoparticles as filler. For this purpose, effect of nanoparticles percent on nanocomposite formation is studied and their physical, mechanical and thermal properties are obtained. The presence of unsaturated polyester in this process forms a cross-link capable of improving the physical and mechanical properties of epoxy resin. Fracture behavior was determined by a SEM device. Moreover, TGA, DSC, impact tests and bending test were applied for data analysis. When process ability is growing, moisture absorption decreases. Fracture toughness was also evaluated in a stoichiometric network. Physical and mechanical properties improve significantly with increasing nanoparticles. The most important reason for using this nanocomposite is its high resistance to corrosion.           Keywords: Unsaturated polyester, Phenol novolac epoxy, Nano Bentonite, Silica nanoparticles, Properties modification.
14 A medical encyclopedia with new approach graphene quantum dots for anti-breast cancer applications: mini review , R.Masoumzadeh1, G.Behbudi2*, S.Mazraedoost2   1 Department of medical, Shiraz University of Medical Sciences, Shiraz, Iran. 2 Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
In Last  years, graphene  quantum dots (GQDs) have received develop consideration due to their attributes such as small size and light weight, fluorescence detects , liquid solvability, biomedicine, photo sensors , drug delivery, gene delivery, and cancer therapy refers to new  approaches. Graphene quantum dots are fluorescent graphene nanostructures with sizes Low. The fluorescence in GQDs emanates through two original the fluorescence emission from bond fracture energy transmission of interlace π-domains and in this material from surface deficiency. The GQDs have found applications in multiple areas such as nano medicine. The GQDs have less toxicity and other particular properties in comparison to materials, quantum dots which make them superior properties for medical applications. In this article, we discuss the applications of GQDs in breast cancer control, drug delivery system and breast cancer treatment. In this work, the articles we used to treat breast cancer are all based on graphene-based conjugates and graphene. In fact, we provide a summary of the latest advances in the treatment of breast cancer using GQD, existing problems and innovative methods. The purpose of this study is to find answers to questions that help us in the treatment of breast cancer, such as why patients do not survive long, a general understanding of the biology of cancer cells and how nanocomponents work in the treatment of these patients. The main purpose of this study was to evaluate GQD as a potential anti-metastatic agent.   Keywords: Graphene quantum dots, Breast cancer, Biomedicine.
15 Nanoparticles induced oxidative stress and related effects especially under exposure to electromagnetic radiations , Sh. Ahmadi1* 1Department of Science, Payame Noor University (PNU), Tehran, Iran.
Electromagnetic fields (EMF) have various chemical effects, including causing deterioration in large molecules in cells and imbalance in ionic equilibrium. Despite being essential for life, oxygen molecules can lead to the generation of hazardous by-products, known as reactive oxygen species (ROS), during biological reactions. These reactive oxygen species can damage cellular components such as proteins, lipids and DNA. Free radicals are unstable atoms or molecules with free outer electrons. This makes them highly reactive because free electrons always strive to form a stable bond. This stabilization involves gaining an electron from another molecule, triggering a chain reaction. Such reactions are omnipresent in the human body, but under certain circumstances can damage biomolecules. Whether nanoparticles are intracellular taken up leading to the activation of free radical production is currently being discussed. Ongoing studies are investigating whether the amount of free radicals formed on the surface of nanoparticles is sufficient to induce cellular effects. This dossier provides an overview about what free radicals are, how they originate, why organisms need them, how they are neutralized, and what we know about the connection between nanoparticles and free radical production. Several studies have reported that exposure to EMF results in oxidative stress in many tissues of the body. Exposure to EMF is known to increase free radical concentrations and traceability and can affect the radical couple recombination. The purpose of this review was to highlight the impact of oxidative stress on antioxidant systems.   Keywords: Electromagnetic fields, Reactive oxygen species, Nanoparticles, Free radical, Antioxidant.
16 Biochemical composition properties of Kombucha SCOBY: Mini Reviews , S.Mazraedoost1*, N.Banaei1   1 Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Kombucha is a fermented tea drink prepared as a result of the symbiotic nature of bacterial cultures and yeast, the so-called SCOBY (Symbiotic Cultures of Bacteria and Yeast). Kombucha is characterized by a rich chemical content and stable properties. Kombucha is a beverage produced by the fermentation of sugared tea using a symbiotic culture of bacteria and yeasts. Kombucha intake has been correlated with certain health benefits, such as: lowered cholesterol and blood pressure levels, decreased cancer spread, improved liver, immune system, and gastrointestinal functions.   Keywords: Kombucha, SCOBY, Biochemical.
17 Preparation of PMMA/nano-SiO2 nanocomposite and its application in formation of microcellular foams using supercritical CO2 , A.Aghili 1*   1 Department of Polymer Engineering, Shiraz Branch, Islamic Azad University, Shiraz, IRAN.
Silica nanoparticles with an average diameter of 12 nm were used for preparation of Poly(methyl methacrylate) (PMMA) nanocomposites using a solution blending method. Dispersion of nanoparticles in the polymer matrix was studied by transmission electron microscopy (TEM). The thermal behavior of polymer and nanocomposites was evaluated by thermogravimetric analysis (TGA). The results showed that the thermal decomposition of nanocomposites occurs at slightly higher temperature compared to the neat polymer. The rheological behavior of polymer and nanocomposites was investigated by an oscillatory rheometer. The pure PMMA and its nanocomposites were used for production of microcellular foams using supercritical carbon dioxide (CO2). Dry ice was used as the source of supercritical fluid. The morphology of microcellular foams was investigated by scanning electron microscopy (SEM) and the cell size and cell density of foams were calculated via image analysis. The effect of silica nanoparticles on cell size and cell density of foams was also investigated. The foams prepared from nanocomposites have smaller cell size and larger cell density.   Keywords: Silica nanoparticles, Supercritical CO2, Microcellular foams.
18 CRISPR/Cas9 as a tool for Genome Editing: A Mini-Review on Development and Approaches , E.Riazimontazer1, 2, 3*, A.Gholami1, 2   1 Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran 2 Pharmaceutical Sciences Research Center, Shiraz University of Medical Science, Shiraz, Iran 3 Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
By introducing recombinant DNA technology, first reported in 1972, biological researchers were able to manipulate DNA molecules to develop new therapeutic strategies. Nowadays, targeted methods for engineering the genome of diverse organisms have provided a powerful tool in treating genetic diseases. Clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR-associated protein 9 (CRISPR/Cas9) technique is one of the newest genome modification tools based on the prokaryotic adaptive immune system. The simplicity and flexibility of the CRISPR/Cas9 site-specific nuclease system and its efficiency have led to its widespread use in many biological research areas. In this review, the basis of this technique and its application in the treatment of genetic diseases are explored while highlighting challenges and future directions. Derived from a remarkable microbial defence system, CRISPR/Cas9 is used widely as an innovative scaffold from basic biology to biotechnology and medicine.                                                                                          Keywords: CRISPR/Cas9, Genome editing, Streptococcus pyogenes, CrRNA, Nuclease.
19 Manufacturing and Properties of Poly Vinyl Alcohol/Fibrin Nanocomposite Used for Wound Dressing , F.S. Hoseini1, R.Taherian1*, A.Atashi2   1 Faculty of Materials Science & Engineering, Shahrood University of Technology, Shahrood, Iran. 2 School of Medicine, University of Medical Sciences, Shahrood, Iran.
The purpose of this study is to make PVA/fibrin nanocomposite with suitable mechanical and biological properties to be used in wound dressing. Characterizations are performed by SEM, microculture Tetrazolium Test (MTT), tensile strength, contact angle, and DAPI coloring. Low, medium and high Concentrations of fibrinogen and thrombin were injected into the scaffolds by electrophoresis method. The tensile strength test of scaffolds shows that the ultimate tensile strength and fracture strain are 4.06 MPa and 0.93, respectively. Wettability and SEM tests show an increase in hydrophobicity by the addition of fibrin to the scaffolds. The DAPI coloring test or cell adhesion test also indicates an increase in cell adhesion of scaffolds contained fibrin in comparison to scaffolds without fibrin. MTT test for 4 days shows a better cell proliferation in the PVA/fibrin composites as compared to PVA scaffolds results Showed that PVA/fibrin nanocomposite could be used for tissue engineering applications as a wound dressing in animal models.                                                                                          Keywords: Adhesive; Biomaterial; Wound Treating; Electrospinning; Nanocomposites.
20 Polyethyleneimine - based materials for gene therapy, bioimaging and drug delivery systems applications , R. Masoumzadeh1*, A. Zare2   1 Department of medical, Shiraz University of Medical Sciences, Shiraz, Iran. 2 Biotechnology research center, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract Polyethylene (PEI) has certain properties that have been widely considered for medical purposes. PEI has a primary, secondary and tertiary cationic structure that gives it special chemical properties that make it have special applications in medicine. The amine groups on PEI are used for biomedical applications such as the preparation of organic / inorganic or organic / organic composites. In this paper, we review the latest scientific advances in medical applications of PEI, such as bioimaging applications, especially cancer diagnosis, gene therapy, and drug delivery systems.     Keywords: Polyethyleneimine, Biomedicine, Gene therapy, Drug delivery systems.
21 Reducing Amination of Aldehydes and Ketons with Highly Branch Polyethylenemine Supported Zirconia Borohydride and Nano Tetrachlorosilane as a New and Mild Reducing Agent , Z. Niknam1, N. Goudarzian1*, Kh.Yousefi2   1Department of Applied Chemistry, College of Sciences, Shiraz University, Shiraz, Iran. 2Department of Materials Science and Engineering, School of Engineering, Shiraz University.
The formation of stable nanoparticle-polymeric reagent obtained by electrostatic complexation is studied in this paper. The nanoparticles placed under scrutiny were nano tetrachlorosilane (SiCl4) reacted with highly branch polyethyleneimine moieties. The complex formation was monitored using different formulation pathways, including direct mixing, sonication, dilution, and quenching. In the first process, the hybrids were obtained by mixing stock solutions of polymer and nanoparticle.  Therefore, the introduction of new and efficient methods is still in demand. The use of heterogeneous catalysts provides a perfect solution to overcome the above limitations.                                                                                          Keywords: Reductive amination, Zirconium borohydride, Polymeric regent, Nano tetrachlorosilane.
22 Covid-19 treatment by plant compounds , S. Mazraedoost1*, G. Behbudi1, S. M. Mousavi2, S. A. Hashemi3   1Biotechnology research center, Shiraz University of Medical Sciences, Shiraz, Iran 2Department of Chemical Engineering, National Taiwan University of Science and Technology, Taiwan 3Department of Mechanical Engineering, Center for Nanofibers and Nanotechnology, National University of Singapore
The COVID-19 pandemic is a global public health epidemic, with significant mortality and morbidity, including critical care, putting a strain on health care services. In the city of Wuhan, China, a novel coronavirus called SARS-CoV-2 appeared at the end of 2019, causing an outbreak of unusual viral pneumonia. A type of coronavirus disease belonging to the family Coronaviridae is COVID-19. Moreover, the disease's symptoms include fever, dry cough, tiredness. It is possible to foresee numerous options to monitor or avoid emerging 2019-nCoV infections, including small-molecule drugs, interferon therapies, and Vaccines. Novel interventions may take a long time. Keywords: Phytochemicals against; Herbal Medicines; Severe Acute Respiratory Syndrome; COVID-19; MERS-CoV; SARS-CoV.