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International Journal of Pharmaceutical Chemistry and Analysis

Journal Papers (7) Details Call for Paper Manuscript submission Publication Ethics Contact Authors' Guide Line
1 Preparation and Evaluation of Polyherbal Hair Oil, X. Fatima Grace, S. Rahul Raj, S. Shanmughanathan, D. Chamundeeshwari
Mankind use various products to enhance beauty and elegance to look young and charming. Cosmetics thus play a vital role in human life. Now a days, herbal cosmetic are widely used because of the belief that they have fewer side effects and better safety. Hair is one of the primary parts of the body which acts as a protective appendage. The objective of the present work is to develop a hair oil for general purpose (daily use) using various herbs. The formulated oil was evaluated for its organoleptic properties, acid value, saponification value, refractive index, pH etc. All the parameters were found to be good and within the standards.
2 Analytical Method Development and Validation for Quantitative Estimation of Torsemide in Bulk and Pharmaceutical Dosage Form by RP-HPLC, Amol. Y. Ghodke, Bhagwat. N. Poul, Mohini. B. Sorde
A simple, specific, precise and accurate Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method was developed and validated for the quantitative estimation of Torsemide in Bulk and Pharmaceutical dosage form. The proposed RP-HPLC method was carried out on Zorbax C18 (250x4.6mm), 5?m column with mobile phase phosphate buffer and methanol (50:50) (v/v). The pH of phosphate buffer was adjusted by Ortho- phosphoric acid to 3.5. The flow rate was 1.3 mL/min and the detection wavelength was 288nm. The retention time of torsemide was found at 6.00.2min. The method was validated for specificity, precision, accuracy, linearity and robustness. The linearity range was 10-30 ?g/mL and correlation coefficient (r2) was found to be 0.9980. The mean % recovery for Torsemide was found to be 99.80. The developed method could be employed for the routine analysis of Torsemide from different formulations and for the Torsemide calculations as well.
3 Enhancement of Solubility of Ezetimibe by Liquisolid Technique, K.S.G. Arulkumaran, J. Padmapreetha
Pharmaceutics is a science of preparing and dispensing drugs. It describes the process involved in turning a new chemical entity into medicine. Pharmaceutical analysis describes the sequence such as identification, quantification and determination of the structure of a particular chemical component that is transformed into a drug. International Journal of Pharmaceutical Chemistry and Analysis (IJPCA) is an international, open access, peer review Journal publishing original research & review articles in all the related fields of Analytical and Pharmaceutical Chemistry.
4 Antimicrobial Activity of Synthesised Novel N10-Alkyl Substituted Acridine-9-one Derivatives, S. K. Gupta, Pankaj Baboo
N-Phenyl anthranilic acid was prepared by Ullmann condensation of o-chlorobenzoic acid and aniline. The N-phenyl anthranilic acid was cyclized with polyphosphoric acid over a water bath at 100C to form acridin-9(10H)-one. N10-Alkylated acridin-9-ones were synthesized in two series, in first series, N10-alkylation with 1-bromo-3-chloro propane and in second series with 1, 2-dichloroethane were done by using tetrabutyl ammonium bromide as phase transfer catalyst. Later both were derivatized by refluxing with different secondary amines in presence of potassium carbonate using anhydrous acetonitrile as solvent. The newly synthesized compounds were purified by column chromatography. The formation of title compounds confirmed by physical and spectral data. The synthesized compounds were subjected to microbiological screening.
5 Anti-Inflammatory, Analgesic and Antimicrobial Activity Studies of Novel 4, 6-Disubstituted-2-Amino-3-Cyanopyridines, Srinivasa Rao Atla, Neelakanta Rao Nagireddy, Rajendra Prasad Yejella
A new series of 4-arylsubstituted-6-(p-hydroxyphenyl/p-aminophenyl)-3-cyano-2-amino pyridines were synthesized by an efficient one-pot cyclocondensation reaction of 4-amino/4-hydroxyacetophenone, aromatic aldehydes, malononitrile and ammonium acetate. The structures of these compounds were confirmed by IR, NMR (1H & 13C) and Mass spectral analysis. All the synthesized compounds were subjected to evaluation for their anti-inflammatory, analgesic and antimicrobial properties. The electro negativity of the substituents and their displacement on the 4- or 6-aryl ring of the 4,6-diaryl-3-cyano-2-aminopyridine nucleus (4a-p) influenced the anti-inflammatory and analgesic activity which was higher in the presence of electron releasing groups. The introduction of the p-hydroxyphenyl substituent in the 6-position of the 3-cyano-2-aminopyridine nucleus (4i-p) increased the anti-inflammatory and analgesic power, but there was no evidence of the relationship among the electronic characteristic of the substituents, their displacement on the 4-phenyl ring and the activity. These results indicated that 4k and 4p are more promising molecules as anti-inflammatory and analgesic agents. All compounds were also evaluated for their antimicrobial activity against variety of bacterial and fungal strains. Compounds 4b, 4f, 4h, 4j and 4p showed maximum activity comparable to the reference standards.
6 Analytical Method Development and Validation for the Estimation of Diltiazem Hydrochloride in Bulk and Pharmaceutical Dosage Form by RP- HPLC, Amol. Y. Ghodke, Bhagwat. N. Poul, Patil Bhagyashree R
A simple, specific, precise and accurate Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method was developed and validated for the estimation of Diltiazem HCl (Diltiazem Hydrochloride) in Bulk and Pharmaceutical dosage form. The chromatographic determination was performed on isocretic High performance liquid chromatography system of Agilent model no.1220. The separation was conducted by using column of Zorbax [C8 (5, 4.6mm250)] with mobile phase consisting of buffer and Acetonitrile in the ratio of (60:40). The mobile phase was delivered at the flow rate of 1.0ml/min. The eluent was monitored at wavelength 240 nm and found a sharp and symmetrical peak with retention time of 4.66min. The method was validated for linearity, accuracy, precision, specificity, robustness. Recovery of Diltiazem HCl was found to be in the range of 98%-102%. The method was found to be linear over the concentration range 50-150 g/ml with coefficient correlation r2 = 0.995. After developing method and studying validation parameter to obtain result complying with USP monograph.
7 Review: Recent Advances in Periodontal Formulations, Mr. Prakash Sapra, Dr. Biraju D Patel, Dr. Dhaval V Patel, Dr. Chetan H Borkhataria
Periodontitis is an inflammatory disease of the supporting tissues of the teeth caused by infection of a periodontal pocket arising from the accumulation of subgingival plaque. Periodontal disease has been considered as a possible risk factor for other systemic diseases such as cardiovascular diseases and pre-term low birth weight infants. Aggressive forms of periodontitis can be localized or generalized. Local delivery of antimicrobial agents using controlled release systems should be considered as adjunctive to mechanical debridement for the treatment of localized forms of periodontal destruction. Systemic administration of drugs leads to therapeutic concentrations at the site of infection, but for short periods of time, forcing repeated dosing for longer periods. Local delivery of antimicrobials has been investigated for the possibility of overcoming the limitations of conventional therapy. The use of sustained release formulations to deliver anti-bacterial to the site of infection (periodontal pocket) has recently gained interest. These products provide a long-term, effective treatment at the site of infection at much smaller doses. This article reviews various types of delivery systems evaluated in practical periodontal therapy and identifies areas where further research may lead to a clinically effective intra-pocket delivery system.