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Journal of Harmonized Research in Pharmacy

Journal Papers (21) Details Call for Paper Manuscript submission Publication Ethics Contact Authors' Guide Line
1 INVESTIGATION ON THE ANTIOXIDANT ACTIVITY OF SESBANIA GRANDIFLORA FLOWER EXTRACT, Biresh Kumar Sarkar*1, Jayesh Mehta1, Gaurav Sharma1, Prashant Soni2
The present study was designed to check the antioxidant activity of Sesbania Grandiflora. The extraction of fruit of Sesbania Grandiflora was carried out by using solvent aqueous methanol. The antioxidant activity of plant Sesbania Grandiflora determined by using different in vitro antioxidant assays. The TP (Total Phenolic) and TF (Total Flavonoid) contents in extracts of the plant Sesbania Grandiflora were found to be in the range of 48.20.74 mcg/mg and 11.750.51 mcg/mg, respectively. The DPPH scavenging activity of extract was found to be in the range of 24.13-64.44%. In conclusion, the extract of Sesbania Grandiflora was found to have potent antioxidant activity which may be due the abundant of phenolic and flavonoid contents. Key words: Antioxidant Activity, Sesbania Grandiflora, Total Phenolic Contents, Total Flavonoid Contents
2 ANTIMICROBIAL EVALUATION AND DETERMINATION OF TOTAL PHENOLIC CONTENT OF MELIA AZEDARACH Biresh Kumar Sarkar*1, Sunil Kumar Punia 1, Monoj Kumar Gupta 1, Shashimindar Yadav2, Prashant Soni2 , Biresh Kumar Sarkar*1, Sunil Kumar Punia 1, Monoj Kumar Gupta 1, Shashimindar Yadav2, Prashant Soni2
Melia azedarach used traditionally for various diseases and infections as per the klowledge of ayurveda. The acetone extraction was carried out of the plant. The phytochemical groups were identified by the tests of characterization and then quantified by the test of total phenolics. Total phenolics were determined using FolinCiocalteu reagent procedure. The total polyphenolic content and flavonoid content in the extract were found to be 71.130.11 mg/g and 11.140.12 mg/g respectively; since antimicrobial activity is related to phenolic compounds contained thus extract was also evaluated for the antibacterial activity. Result of study suggested that Melia azedarach having great potential as antibacterial agent. The extract at dose level of 200 mcg/ml showed highest inhibition against P. aerugunosa, S. aureus and E. coli. Keywords: Melia azedarach, Total phenolics, Total flavonoids, Antimicrobial.
3 POWDER MICROSCOPY AND PHOTOMICROGRAPHY STUDY OF BUTEA MONOSPERMA GUM., Deenanath Jhade*, Dheeraj Ahirwar, Neeraj K Sharma, Sunita Jhade
Abstract The powder microscopy and photomicrography study was carried out on the gum of Butea monosperma (Lam.)Taubert belonging to the family leguminaceae, which showed the largest body of the mucilage is 400 m in diameter, pollen grain was upto 40 m in diameter and the largest crystal of calcium oxalate was 110 m thick in rhomboidal to polyhedral in shape when seen under the polarised light. Key-word: Butea monosperma, pollen grain, calcium oxalate, rhomboidal, polyhedral.
4 IN-VITRO FREE RADICAL SCAVENGING ACTIVITY OF LORANTHUS ELASTICUS DESV., Othbert Pinto, Chandan H R, Nayimulla Shariff3, Suresha RN and Naveen S
Abstract Enhancing the shelf life of any product with natural extract from natural source is most desirable. These extracts with known and unknown bioactive compounds can also be exploited to inhibit the oxidation in human system. In the present study, different solvent extracts of Loranthus elasticus Desv have been assessed for their antioxidant potentials by five methods selected which represents lipid peroxidation occurring in both foods as well as in biological system. The eextract showed good antioxidant activity except Iron chelating activity; both ethanol and methanol extracts have shown impressing level of the free radical scavenging activity, which were comparable to synthetic antioxidant such as BHA, TBHQ etc. Utilization of the extract may result in formulating better health care products with enhanced shelf life and little or no side effects. Key words: Antioxidants, Loranthus elasticus, DPPH, Metal chelating, Nitric oxide scavenging and 2-deoxy-D-ribose degradation.
5 PHYTOCHEMICAL ANALYSIS ON ASYSTASIA GANGETICA (L.) T. ANDERSON, Janakiraman N, Jasmin Jansi J, Johnson M*, Jeeva S, Renisheya Joy Jeba Malar T
Abstract The present study was aimed to scrutinize the phytochemical components present in the various extracts of Asystasia gangetica (L.) T. Anderson using FT-IR, TLC and GC-MS. Preliminary phytochemical screening of the extracts was carried out using the standard method. The crude powder of A. gangetica was passed into the FT-IR and the peak values were recorded. TLC profile for phenolics and steroids was done using the mobile phase chloroform and methanol (9:1) and benzene and methanol at 9:1 ratio respectively. GC-MS analysis was performed on the benzene extracts to find out the chemical constituents. Preliminary phytochemical investigation confirmed the presence of various primary and secondary metabolites with varied degree. FT-IR spectrum revealed the functional constituents present in the crude powder of A. gangetica. TLC profile showed distinct bands with varied Rf values. GC-MS analysis results leads to the identification of 27 different compounds. The findings of the present study recommended the use of A. gangetica for developing plant based drugs for various ailments. Further study is recommended on other constituents on a road map of development of other phyto-pharmaceuticals for disease management. Key Words: Phytochemical, Asystasia gangetica, Pharmaceuticals, Metabolites
6 EVALUATION OF FREE RADICAL SCAVENGING ACTIVITY OF THE DIFFERENT FRACTIONS OF TYPHA LATIFOLIA. (TYPHACEAE)., Rahul Shukla, Sajal Srivastava, Parmesh K. Dwivedi, Saikat Sarkar, Sumit Gupta and Ashutosh Mishra
Abstract: We have investigated different parts of Typha latifolia in pursuit of unraveling its oxidant quenching ability and discover novel, prudent and inexpensive antioxidants. Samples of rhizome, shoot, leaves and pollen from Typha latifolia were tested for total phenolic content, and flavonoids content and in vitro antioxidant activity by diphenyl-1-picrylhydrazyl (DPPH) assay. The extracts exhibited strong antioxidant activity with IC50 values of ethyl acetate extract 6.72 g/ml, 34.06 g/ml, 16.4 g/ml, 9.6 g/ml, methnolic extract 230 g/ml, 301.32 g/ml, 213.5 g/ml and 11.7, Aqueous extract 4.5 g/ml, 2.45 g/ml, 35.47 g/ml, 9.3 g/ml of rhizome, shoot, leaves and pollens respectively. IC50 value of standard ascorbic acid was 2.69 g/ml. Total phenolic content was measured in mg catechin equivalent/g dry weight (g CE/mg). Ethyl acetate, methnolic, aqueous extract of rhizome and pollen showed higher values i.e. 102.17.55, 94.1710.13, 109.251.67, 140.877.01, 137.044.13, 230.5 1.41. Total flavanoid was calculated in mg rutin equivalent/g dry weight (g RE/mg). Ethyl acetate, methnolic and aqueous extracts of pollen showed higher value i.e. 46.240.39, 71.870.45, 53.92 5.47. Tests have shown high percentage of presence of alkaloids, sterols, sugars, flavonoids and tannins in different extracts of rhizome, leaf, shoot and pollen. These results allude that Typha latifolia has strong antioxidant potential. But, further scrutiny is essential for isolation and characterization of the active anti-oxidative components, which can be employed to allay various oxidative stress-related maladies. Key words: Typha latifolia, chemical, medicine, nutritive, region, wetland, antioxidant activity, DPPH, different extracts, IC50 value.
7 DEVELOPMENT OF NEW UV SPECTROSCOPIC METHOD FOR THE ESTIMATION OF EMTRICITABINE IN BULK AND CAPSULS , PRADEEP KUMAR*, DHIRENDER SINGH MITTAN, NARESH KUMAR
Abstract: A simple and sensitive spectroscopic method in ultraviolet region was developed for the estimation of Emtricitabine in Bulk and pharmaceutical dosage forms. The method is based on Emtricitabine, showing absorbance at 278 nm for zero order spectroscopy in distilled water. The method obeys Beers law in the concentration range of 40 to 400?g/ml. The proposed method is precise, accurate, linear, stable and reproducible and can be extended to the analysis of Emtricitabine in bulk and pharmaceutical formulations. Key words: Emtricitabine, U.V spectroscopic, U.V estimation.
8 ANXIOLYTIC EFFECT OF MYRISTICA FRAGRANS, Shripad Ingale*, Beere Nagaraju, Dr Ravi CM, Ali Bolouri, Surendranatha A, Dr Bhushanam YC
Abstract Background and Objectives: The use of Myristica fragrans as an anxiolytic agent has been mentioned in the ayurveda but still no study has been reported. The present study was evaluated for its anxiolytic activity using Open field model. Methods: In the open field test, the parameters measured were ambulation, rearing, grooming, and fecal pellets. Results: In the open field test the Myristica fragrans at doses of 25mg/kg and 50mg/kg significantly increased the number of ambulations and rearing. The Myristica fragrans at doses 25mg/kg and 50mg/kg significantly decreased the number of grooming and fecal pellets. Myristica fragrans showed anxiolytic activity in dose dependant manner. Interpretation and conclusion: Myristica fragrans at doses of 25mg/kg and 50mg/kg possess anxiolytic activity in the model tested and was found that higher dose (50mg/kg) was more significant than lower dose (25mg/kg). More investigations are necessary to prove the anxiolytic activity of Myristica fragrans by other models. Further the molecule responsible for the anxiolytic activity can be separated and identify the mechanism of action. Key words: Myristica fragrans; Open field; ambulation, rearing,grooming, fecal pellets.
9 A REVIEW ON HERBAL MEDICINAL PLANTS FOR THE TREATMENT OF OBESITY, Neeraj Kumar Sharma*, Dheeraj Ahirwar
Abstract: This study is for the effects of some Indian medicinal plants that are claimed to be useful in the treatment of obesity are reviewed. Research studies are being carried out to detect and confirm the action of drugs and natural products that yield better and long-lasting results in terms of weight reduction. In this field, medicinal plants play a pivotal role. The statins inhibit 3-hydroxy-3- methylglutaryl coenzyme A (HMG-CoA) reductase and, thereby, suppress cholesterol biosynthesis. Keywords: Obesity, Herbal medicines, lipid lowering, anti-obesity
10 Phytochemical Studies on Ulva lactuca Linn., Babu A, Johnson M*, Patric Raja D
Abstract The present study was aimed to explore the phytochemical constituents present in various extarcts of Ulva lactuca Linn and produce the FT-IR, TLC, UV-VIS and HPLC spectrum profile for U. lactuca. Phytochemical screening of the extracts was carried out according to the method described by Harborne. For the HPLC analysis, the methanol: water (45:55) was used as mobile phase. The results of phytochemical analysis revealed the presence of steroids, phenolic groups, alkaloids, saponins, tannins, glycosides and terpenoids in U. lactuca. The UV- VIS profile of aqueous, ethanolic, chloroform, petroleum ether and hexane confirmed various metabolites and functional groups presence in the crude extracts of U. lactuca. The HPLC profile of U. lactuca ethanolic extract showed some prominent and moderate peaks with different retention time. The results of the present study showed that U. lactuca may be rich sources of phytoconstituents which can be isolated and further to exploit for developing plant based drugs for various ailments. Keywords: Ulva lactuca, Phytochemistry, TLC, FT-IR, UV-VIS, HPLC
11 POLYSACCHARIDE EXTRACTS FROMSARGASSUM SILIQUOSUMJ.G. AGARDH MODULATES PRODUCTION OF PRO-INFLAMMATORY CYTOKINES IN LPS-INDUCED PBMC AND DELAYS COAGULATION TIME IN-VITRO, Ross D. Vasquez , Ruby SP. Garcia-Meim, John Donnie A. Ramos
Abstract Sulfated polysaccharides from brown seaweeds exhibit various biological activities, structural diversity, and are potential reagents for the development of therapeutic drugs. This study aimed to determine the effect of aqueous (AQ) and fucoidan (F1) extracts fromSargassumsiliquosumJ. G Agardhon viability of peripheral blood mononuclear cells, production of pro-inflammatory cytokines and plasma coagulation using in vitro assays. Sulfate contents of the polysaccharides were quantitated using Acid-Ashing Digestion Ion chromatography. Effects on viability of the extracts on peripheral blood mononuclear cells (PBMC) wasdetermined by MTT Assay. Estimation of pro-inflammatory cytokines concentrations was done through Enzyme-Linked Immunosorbent Assay (ELISA), while anticoagulant activity was measured by Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT). Results revealed that both extracts were non-cytotoxic to PBMCs, reduced significantly the production of IL-1, IL-6, TNF-? and exhibited normal anticoagulant activity in PT assays and prolonged APTT remarkably in dose-dependent manner. In conclusion, extracts of the Sargassumsiliquosum J.G. Agardh is a potential alternative source in producing anti-inflammatory and anticoagulant substances in the future.
12 SYNTHESIS AND EVALUATION OF THIAZOLIDINE-4-ONE FOR THEIR ANTIBACTERIAL ACTIVITY, Tribhuvan Singh*, Deepak Khobragade
Abstract: A new series of Thiazolidine-4-one showed diversified antibacterial activities. In view of potential antibacterial activities of thiazolidine-4- one derivative were prepared by schiffs base technique. The compound were screened by antibacterial activity, thiazolidine -4-one also showed antifungal acyivity, hypoglycemic activity, anti-convulsant activity, analgesic activity, anti-tubercular activity and anti-inflammatory activity.Thiazolidine-4-one also related to ketone group, amine group, sulpher group and thiazolidine ring. Key Words: Schiffs base. Thiazolidine -4- one. Anti-bacterial activity.
13 FORMULATION AND EVALUATION OF SATRANIDAZOLE TABLET FOR COLON DELIVERY, G.N. Darwhekar*, Dr. D.K Jain and Arpit Kapoor
Abstract: Literature survey reveals that, amoebiasis is the second leading cause of death from parasitic disease worldwide. The causative protozoan parasite, Entamoeba histolytica, is a potent pathogen. Oral delivery of drugs in the colon is valuable in the treatment of diseases of colon like amoebiasis whereby high local concentration can be achieved while minimizing side effects. Satranidazole was selected as the drug of choice because it is most potent nitroimidazole derivative and clinically useful against common protozoa; it is twice as effective as other nitroimidazole against amoebiasis. Colon targeted tablet of satranidazole can maintain minimum inhibitory concentration (MIC90) for desired duration in fewer doses and even with fewer side effects. The colon targeted matrix tablet of satranidazole which is composed of polysaccharides which are susceptible to enzymatic degradation i.e. Guar gum, Xanthan gum, Guar: Xanthan gum in combination at 2 ratios (1:1) and (2:1) and Pectin coated with enteric polymer Eudragit L, Eudragit S and Eudragit RS in ratio of 4:16:5 with less quantity of plasticizer PEG 400 showed excellent film properties and were able to release most of the drug into colon. 10% of coating was found to be optimum. Analytical methods were developed for the drug, and calibration curves were prepared in SGF, SIF, and SCF. Formulation SF7 was considered as optimum batch as it delivered 96 % of drug into colon. The in vivo studies showed that tablet does not disintegrate in stomach and small intestine and site of disintegration was found to be descending colon. The formulation SF7 can be employed as a promising colon specific drug delivery system of satranidazole. Keywords- Satranidazole, Colon targeted tablets, Guar gum, Xanthan gum, Pectin, X-Ray Study
14 ANTI-INFLAMMATORY ACTIVITY OF LEAF AND BARK OF HUGONIA MYSTAX L. (LINACEAE), G. Rajeswari, M. Murugan and V.R. Mohan
Abstract: Objective: In the present study anti-inflammatory activity of ethanol extract of leaf and bark of Hugonia mystax were inveatigated. Methods: The anti-inflammatory activity of ethanol extracts leaf and bark of H. mystax were evaluated by carrageenan induced rat paw edema to determine its effect on chronic phase of inflammation models in rats. Results: Preliminary phytochemical analysis of ethanol extracts of leaf and bark showed the presence of alkaloid, catechin, coumarin, flavonoid, tannin, saponin, steroid, phenol, glycoside, terpenoid and xanthoprotein. Maximum inhibition (83.91%) was obtained at the dose of 500 mg kg -1 of H. mystax leaf after 3 hours of drug treatment in carrageenan induced paw edema, whereas, indomethocin produced 84.82% of inhibition. Conclusion: The present study suggests that H. mystax leaf and bark extrats possess strong antiinflammatory property so it has immense scope as an effective source to develop drug for the treatment of inflammatory related diseases. Key words: Anti-inflammatory, paw edema, Hugonia mystax
15 IMMUNOMODULATORY ACTIVITY OF ETHANOL EXTRACT OF SARCOSTEMMA SECAMONE (L.) BENNET (ASCLEPIADACEAE) IN MICE, Thangakrishnakumari S, Nishanthini A, Muthukumarasamy S, Mohan V.R
Abstract: Sarcostemma secamone (L.) Bennet an ethnomedicinal plant was studied for its immunomodulatory activity. Immunomodulatory activity of different doses of ethanol extract of Sarcostemma secamone was evaluated in Swiss albino mice. Mice were treated with two doses (150 and 300mg/kg body weight) for 5 days. Body weight, relative organ weight, delayed type hypersensitivity (DTH) response and Haemagglutionation titre (HT) were studied in various groups of animals. The results obtained show a significant increase (p
16 ESTIMATION OF TOTAL FLAVONOIDS CONTENT (TFC) AND ANTI OXIDANT ACTIVITIES OF METHANOLIC ROOT EXTRACT OF CLERODENDRUM INFORTUNATUM LINN, Pallab Kalita, Prof. (Dr.) Tapan Kumar Barman*, Prof. Tapas Kumar Pal
Abstract: Clerodendrum infortunatum(C.I.) Linn. (Lamiaceae), commonly known as Bhant in Hindi, is a small shrub occurring throughout the plains of India. This plant has been used in Indian folk medicine in the treatment of bronchitis, asthma, fever, burning sensation, diseases of the blood, inflammation, and epilepsy. The total flavonoid content of methanolic root extract of C. infortunatum (MECI) was determined by using aluminium chloride colorimetric method. It was found that Clerodendrum infortunatum root extracts contain total flavonoids in 0.0055% gm quercetin equivalent per gram of extract. In this study phytochemical analysis of methanolic extract of C. infortunatum L. has indicated the presence flavonoid . Since these compounds are of pharmacological interest, coupled with the use of this plant in traditional medicine, prompted us to check C. infortunatum L. for possible antioxidant activity by DPPH scavenging activity and reducing power ability. The maximum percentage inhibition by DPPH method was found about 92.99 at concentration of 110.46?g/ml, when compared with Quercetin. The reducing capabilities were found to be in dose dependent manner. Key words: Clerodendrum infortunatum, aluminium chloride, quercetin, DPPH
17 ANTI-DIARRHOEAL ACTIVITY OF POLYCARPAEA CORYMBOSA (L.) LAM. WHOLE PLANT EXTRACTS (CARYOPHYLLACEAE), Balamurugan K, Sakthidevi G, Mohan V.R
Abstract: The objective of this study was to investigate the anti-diarrhoeal activity of whole plant of Polycarpaea corymbosa in rats. Anti-diarrhoeal effects of the ethanol extracts at 100, 200 and 400 mg/Kg were evaluated in rats using castor oil induced models. Results showed that the ethanol extract exhibited significant and dose dependent anti-diarrhoeal activity in the model used. A percentage diarrhoeal inhibition of extract at 400 mg/Kg was 75.63%. Diarrhoeal protection in the model used by the extract is dose dependent and the diarrhoeal inhibitory effects of the extract are comparable to loperamide. Therefore, a result of present study suggests that the ethanol extract of Polycarpaea corymbosa possesses anti-diarrhoeal activity. Keywords: Polycarpaea corymbosa, anti-diarrhoea
18 TERPENOIDS PROFILE OF CLITORIA TERNATEA LINN, Selvamaleeswaran Ponnusamy, Wesely Ebenezer Gnanaraj, Johnson Marimuthu Antonisamy
Abstract: The present investigation was aimed to reveal the terpenoid profile of Clitoria ternatea Linn seed, stem and leaves using HPTLC. Preliminary phytochemical screening was carried out by Harborne method. HPTLC studies were followed by Harborne and Wagner et al. method. The n-hexane-ethyl acetate (7.2:2.9) was employed as mobile phase for terpenoids. The methanolic extracts of Clitoria ternatea stem, leaves and seeds showed the presence of 23 different types of terpenoids with 17 different Rf values with range 0.01 to 0.92. In general more degree of terpenoids diversity has been observed in vegetative parts when compared to the reproductive part (Seed). Maximum number [9] of terpenoids has been observed in leaves followed by seed (8). The proposed HPTLC profile can be used for the identification of the medicinally important plants and distinguish from its adulterant. Keywords: HPTLC; Terpenoids; Clitoria ternatea; Phytochemistry
19 PHARMACOCHEMICAL CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY ASYSTASIA GANGETICA (L.) T. AND., Daffodil E.D, Packia Lincy M, Pon Esakki D, Mohan V.R*
Abstract The present study has been carried out to evaluate the pharmacochemical characterization and in vitro antibacterial activity of the whole plant extracts of Asystasia gangetica. Physicochemical parameters parameters (Ash value and extractive value; fluorescence analysis) and phytochemical analysis were done by using the standard methods. The petroleum ether, benzene, ethyl acetate, methanol and ethanol extracts were tested against Bacillus thuringiensis, Streptococcus faecalis, Staphylococcus aureus, Salmonella paratyphi, Proteus vulgaris, Serratia marcescens by the agar disc diffusion method. The total ash value of whole plant of Asystasia gangetica is 10.14%.. The extractive value of water is more than in the solvents investigated. Preliminary photochemical screening of whole plant showed the presence of alkaloids, tannins, terpenoids, xanthoprotein, and sugar in the methanol and ethanol extracts. The whole plant extracts of Asystasia gangetica showed potent antibacterial activity. The present investigation, whole plant of Asystasia gangetica revealed the high degree of antibacterial against Salmonella paratyphi. The pharmacochemical characterization will be helpful to study the active principles using modern techniques in the later part of this work. Key Words: Asystasia gangetica, fluorescence analysis, Phytochemical, Antibacterial.
20 ROLE OF ANTI-INFLAMMATORY AGENTS AS A TREATMENT OF MULTIPLE SCLEROSIS, Anamika Saxena*, Ashok Dashora Virendra Singh and A.K.Akhtar
ABSTRACT Multiple sclerosis (MS) is a neurodegenerative disease in which the immune system recognizes proteins of the myelin sheath as antigenic, thus initiating an inflammatory reaction in the central nervous system. It is characterized by intermittent or chronic damage to the myelin sheaths (demyelination), focal inflammation and axonal degeneration Inflammation has always been as the pathophysiology of multiple sclerosis. The present pharmacological treatment of MS administration of immunomodulatory and anti-inflammatory drugs, which are only palliative and slow progress of the disease. Infection, trauma or autoimmune inflammation in experimental allergic multiple sclerosis and they are competent presenters of antigen and interact with T cells recruited to the inflamed CNS. Symptoms of inflammation in general and more specifically in multiple sclerosis, a demyelinating, autoimmune disease characterized by inflammation of the central nervous system (CNS). Inflammation has always been thought of as detrimental in the pathophysiology of multiple sclerosis. However, emerging genetic data, magnetic-resonance-imaging studies, and immunopathological evidence challenge this simplistic view. Inflammatory cells normally occurs via emigration or insitu apoptosis. Characterization of the inflammatory infiltrates present in MS brain and spinal cord tissue. Studies in of myelin proteins can become immune system targets resulting in demyelination, and these models have also served to define multiple immunological mechanisms of disease. Primary inflammatory cytokines and chemokines with a proretention activity have been found in active MS. Plaquesfocal inflammation and axonal degeneration. During the early relapsing/remitting stages of MS, myelin can regenerate, but as the disease progresses the remyelination of axons becomes insufficient, leading to impaired axon conduction, neurodegeneration and the worsening of symptoms. The rationale to influence immunological activity in MS is to suppress myelin and axonal damage and thus to prevent clinicaldisability. Key Word: Anti-inflammatory, multiple sclerosis
21 A REVIEW ON CANNA INDICA LINN: PHARMACOGNOSTIC AND PHARMACOLOGICAL PROFILE, Sanchalika Mishra, Ashutosh Yadav, Sandeep Kumar Singh
Abstract In recent years, ethnobotanical and traditional uses of natural compounds, especially of plant origin received much attention as they are well tested for their efficacy and generally believed to be safe for human use. Canna indica commonly known as Keli is widely cultivated throughout India, tropical and sub-tropical regions of Southern United State and South to Northern Argentina & Philippines in settled areas belongs to the family Cannaceae. It widely used as a nutritive agent and possesses number of valuable pharmacological activities. This article aims to provide information which is required to claim and explore its pharmacognostic and pharmacological profile. Every part of Canna has beneficial properties that can serve humanity so the whole plant can be extensively studied for further research aspects. Keywords: Canna, hepatoprotectives, pharmacology, antioxidant activitiy, HIV type 1 reverse transcriptase inhibitor activity