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International Medicine

Journal Papers (14) Details Call for Paper Manuscript submission Publication Ethics Contact Authors' Guide Line
1 Concealed electrocardiographic features in arrhythmogenic cardiomyopathy, Stefan Peters
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2 Inflammation in the lung today, hyperbolic perceptions of infection, Igor Klepikov
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3 Human cystic echinococcosis, trichinellosis, and toxocariasis in Bulgaria: an update of data for 2015-2017, Rumen Harizanov, Iskra Rainova, Iskren Kaftandjiev
Background: The purpose of our study is to perform a retrospective analysis of the prevalence of some zoonotic helminth infections (trichinellosis, cystic echinococcosis, and toxocariasis) for the period 2015-2017, given their important medical and social significance for the public health system in Bulgaria and other endemic countries. Methods: We used data from the National Centre of Infectious and Parasitic Diseases and Regional Health Inspectorates for all registered cases of cystic echinococcosis and trichinellosis during the study period and data from the Department of Parasitology and Tropical Medicine on all cases seropositive for toxocariasis. Results: For the study period in the country were reported 800 confirmed cases of hydatid disease of which 715 (89.4%) primary and 85 (10.6%) cases of relapse. The group of children and adolescents accounted for 21% of the total number of infected. Ten trichinellosis outbreaks were also recorded, involving the population of 16 settlements across 10 of the 28 districts of the country. Contaminated with Trichinella larvae meat was consumed by 293 persons of whom laboratory confirmed infection was found in 113 individuals (38.6%). For the period, 408 persons with clinical symptoms suspicious for toxocariasis were tested and 78 (19.1%) of them were positive for the presence of specific anti-Toxocara antibodies. Conclusions: Parasitic zoonotic diseases have endemic spread in many countries around the world and pose a problem for public health. We present data on three helminth diseases, two of which (cystic echinococcosis and trichinellosis) are still widespread in Bulgaria and are of great medical and social importance.
4 The status of newly graduated nurses being subjected to violence, Sevgul Donmez, Sureyya Gumussoy
Background: Violence is an important social health issue that can be seen in all fields of human life and it has been gradually rising all over the world. Violence has been spreading into areas like schools, hospitals, public institutions and threaten social peace and creates stress. This research was planned to determine the status of newly graduated nurses being subjected to violence in the fields of application during undergraduate education. Methods: The research was carried out descriptively between June to August 2018 with 267 nurses who subscribed to Internet sites and groups that were constituted related to the nursing profession. As a data collection tool, an online prepared “Identification Form” containing 22 questions was used. During the evaluation of data average, number, and percentage were used. Results: It was identified that 84.6% of nurses were exposed to verbal violence, 2.2% to physical violence, and 4.9% sexual violence throughout the undergraduate education. When the job performance of nurse who suffered from violence was scrutinized it was observed that 79.0%’s motivation decreased, 58.1% thought that their profession was not respected, 36.7% delineated from occupation, 19.9% thought that they could not overcome the difficulties of the occupation, and 19.5% though to quit occupation. Conclusions: It was determined that the type of violence that nurses often exposed to at the fields of the application was verbal violence. They frequently received violence from patient relatives and their post-violence job performance and professional perception were influenced negatively.
5 Fertility characteristics of a province in eastern Turkey , Nursel Alp Dal, Sureyya Gumussoy, Yeliz Cakır Kocak
Background: The aim of this research was to evaluate the fertility rate of Tunceli, a province located in eastern Turkey and rapidly changes over time, and the factors thought to be effective in the change. Methods: The research had a cross-sectional design. The sample of the study consisted of 356 women. The data of the study were obtained using a questionnaire that consists of 41 questions by face to face interview technique. Results: The mean age of the women who participated in the research was 36.49±7.07, the mean first gestational age was 25.20±3.75, the mean number of pregnancies was 1.85±0.91, and the mean parity was 1.74±0.84. The first labors of 70.5% of the women were normal vaginal delivery, 52.0% used an effective family planning method, and 95.5% could easily reach the methods. In the study, it was determined that there was a negative, moderate, significant correlation between the first marriage age and the mean number of pregnancies, that the number of pregnancies and parity increased significantly as the educational level of women decreased, that the number of pregnancies and parity increased significantly as the educational level of spouses of women decreased and that the number of pregnancies and parity decreased significantly as the level of income of family increased. Conclusions: In the research, the fertility of women was found to be associated with some sociodemographic characteristics. For this reason, improvement of sociodemographic characteristics that may negatively affect the fertility should be supported.
6 Effects of virtual reality based physical therapy interventions on balance and gait performances of chronic hemiparetic stroke patients: a literature review, Michael Jung, Eric Steeves
Background: Approximately 795.000 strokes occur each year in the United States of America. On average, every 40 seconds, an American suffers a stroke. Hemiparesis is a common post-stroke symptomatic condition (about 8/10 stroke survivors), with dramatic impact on balance, gait, and activities of daily living. Approximately 2/3 of stroke survivors need an intensive rehabilitation provided by multidisciplinary teams, in which physiotherapy plays a significant role. The primary objective of this study is to clarify if virtual reality- based therapy can offer a genuine clinical alternative to conventional physical therapy in the treatment of chronic hemiparetic stroke patients, helping physiotherapists and individuals reach higher rehabilitation performance outcomes in terms of balance and ambulation. Methods: A systematic review was conducted in the Physiotherapy Evidence Database (PEDro). Studies published after 2007 were searched. Results: Clinical trials including virtual rehabilitation interventions for stroke patients started to appear in the early 2000s. Meanwhile, the latest Cochrane systematic review titled “Virtual reality for stroke rehabilitation” includes 72 trials involving 2470 participants, showing an increasing therapeutically interest. Conclusions: The three trials presented in this essay show that balance recovery benefits most from a combination of virtual reality- based and conventional physiotherapy. Moreover, virtual task-oriented exercises can be enjoyable and motivating, increasing patient compliance to rehabilitation.
7 The pitfalls of crowdfunding Alzheimer’s disease research, Mario D. Garrett
With pharmaceutical companies’ repeated failures at finding effective interventions for Alzheimer’s disease, together with an increasing reliance on the growing federal funding for research, there is an emergent opportunity for financing alternate research through crowdfunding. Crowdfunding—where funding is obtained from small donations from a large group of people—has become a new source of funding for medical research. By understanding how the research community has evolved to study Alzheimer’s disease the pitfalls of this strategy can be highlighted. Alzheimer’s disease research is complex. From its inception in the early 1900s, Alzheimer’s disease has been at the center of movement within psychiatry to define the disease on the basis of its biology. Recent emphasis— through the DSM (Diagnostic and Statistical Manual of Mental Disorders), RDC (Research Diagnostic Criteria), RDoC (Research Domain Criteria) as well as the more recent Framework from the U.S. National Institute on Aging—have supported an exclusive emphasis on biology. But by excluding other aspects of the disease, such as its clinical expression, this research approach will be shown to be faulty and contradictory. So far, this approach has resulted in 100% failures. By examining the historical and financial circumstances of the industry centered on Alzheimer’s disease a strong warning is given to the public to mistrust crowdfunding Alzheimer’s disease research. A broader and more inclusive approach is likely to generate a better understanding of the disease and therefore hold better promise for understanding the disease in the long term. Such a nuanced approach competes badly with the more binary search for a cure and is less receptive to public support through crowdfunding.
8 Analysis of digital histopathology images for breast cancer diagnosis, Samir Kumar Bandyopadhyay
Significant development of mammogram-based computer-aided diagnosis using image processing techniques has been reported by different research articles. Huge opportunity still persists to develop a fully automatic system to detect abnormalities and predict future risk factors. Digital histopathology analyzes breast biopsy slide image for diagnosis of breast tumors.
9 Tumor lysis syndrome associated with renal cell carcinoma, Jeffrey Frank Wang, Ross Daniel Luther, Daniel Mass, Jue Wang
Background: Tumor lysis syndrome (TLS) is an oncologic emergency which has been extensively documented in patients with hematological malignancies, but rarely described in patients with renal cell carcinoma (RCC). The objective of this study was to investigate the clinical characteristics and outcomes of TLS, a rare but life-threatening complication in RCC. Methods: Retrospective literature review and pooled analysis. Results: Ten cases of TLS were identified in patients with metastatic RCC (eight cases in published literature and two cases from our tumor registry). The median age of patients was 60 years (45-88). Seven cases (70%) of TLS were associated with a variety of treatment regimens, include sunitinib (42%), pazopanib (14.2%), nivolumab (14.2%), nivolumab and Ipilimumab (14.2%), and temsirolimus (14.2%). The median time to TLS from treatment 16 days (14-28). Three (33%) patients had spontaneous TLS. All patients had extensive metastatic disease at the time of presentation, with visceral metastases documented in 100% of TLS cases. The majority of cases were clear renal carcinoma (one case of sarcomatoid, and another with extensive rhabdoid feature). All cases were treated with aggressive supportive measures, and four patients received rasburicase. The mortality rate was 57% among seven cases of treatment related TLS. The mortality rate was 100% in the three patients with spontaneous TLS. Conclusions: TLS in RCC can occur both after treatment and spontaneously, and is associated with very high mortality. Our findings underscore the importance of heightened awareness, risk assessment, and early prevention of this previously underdiagnosed oncologic emergency.
10 Tuberculosis: a short glimpse, Ahtesham Ahmad Shad, Wajahat Ahmed Shad
Mycobacterium tuberculosis is an acid-fast bacterium, that cause the disease of significant burden worldwide i.e. tuberculosis (TB). Because of its airborne transmission, it remains a milestone and a very strong hurdle to limit its spread. More significantly, its targeting area mostly is alveolar macrophages present in the lungs, in which it can reside as a silent killer. This mini review aims to highlight the fundamentals of Mycobacterium tuberculosis, its disease-causing pattern, and treatment options that have been developed to tackle the disease. TB has been categorized into re-emerging disease in many parts of the world, so there is a need to look on it. Further prevention and controlling strategies also discussed in last to highlight the importance in which sense the TB prevalence could potentially be reduced.
11 Left posterior chest wall reconstruction using a prolene mesh following wide local excision of nodular fasciitis: a case report, Mior Faiq Mior Abu Tahrin
Nodular fasciitis (NF) is a benign, self-limiting condition that is characterized by myofibroblast/fibroblast proliferation. It is commonly seen at the back, trunk, and upper limbs (the volar aspect of the forearm). Patients who are diagnosed with this condition typically present with a history of rapidly enlarging subcutaneous mass over several weeks or months. NF often mimics a malignant process due to rapid growth clinically, high mitotic activity and cellularity, and nonspecific cytomorphologic findings which make the diagnosis pretty challenging. In this paper, we described a case of NF of the left posterior chest wall who underwent wide local excision followed by chest wall reconstruction using a prolene mesh.
12 Diplopia as an alarm sign in orbital traumatism, Eduardo Esteban-Zubero, Kevin Verney Lafont-Jiménez, Cristina García-Muro, Moisés Alejandro Alatorre-Jiménez, Alejandro Marín-Medina, Carlos Arturo López-García, Daniela Delgado Lara, Viridiana Ramírez Ramírez
Orbital fractures represent between 10% and 25% of all facial fractures. They may be classified into three types: a) orbital rim fractures, b) comminuted fractures of the orbital wall (the most frequently observed), and c) "trap door" fractures of the orbital wall. This pathology is more relevant in traffic accidents due to its greater complexity given the appearance of concomitant injuries. The most frequent clinical signs observed in adults in orbital fractures are periorbital ecchymosis and subconjunctival hemorrhage, although symptoms related to proptosis, feeling of orbital or eyelid pressure, a "crackling" sound with the eyelid pressure or eye movement, numbness of the cheek, nasal wing or ipsilateral forehead, diplopia, pain or nausea in a particular direction of the gaze, and an unexplained desire to keep the eye closed after a trauma. The standardized diagnostic method for the diagnosis of orbital fractures is the computerized axial tomography (CT), being ultrasound and cone beam CT equally useful in some cases. Attending to the treatment, conservative management may be performed, requiring surgery within two weeks if persistent diplopia is found, enophthalmos >2 mm, orbital floor fracture >50%, or associated fractures which requires surgery. Hereby, we realize a short review of orbital fractures a purpose of a case report of 85-year-old man which suffered a left hemifacial traumatism. A CT was performed showing a fracture of the floor of the left orbit (left maxilla) with signs of entrapment of the left inferior rectus muscle.
13 A large incidental adrenal mass in a patient with sudden onset multiple organ failure, Run Yu
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14 The case when anatomist and surgeon Gaspare Tagliacozzi offended God: an endless clash between religion and medical ethics, Gregory Tsoucalas, Eleni Panagouli, Vasilios Thomaidis
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