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Paper Details

Synthesis and pharmacological properties of 4- (Substitutedbenzylidene)-2-phenyl-1-(5-(pyridin-4- yl)-1, 3, 4-thiadiazol-2-yl)-1H-imidazol-5(4H)-one

Sudhir Bhardwaj1* Narendra Parashar2 Manisha3 and Vandana Gurg4

Journal Title:Journal of Chemical, Biological and physical sciences
Abstract


Microwave-induced organic reaction enhancement (MORE) has gained popularity as a nonconventional technique for rapid organic synthesis in the last few years. Reactions in domestic microwave ovens are currently in use for the synthesis of medicinally important compounds. Within the framework of Green Chemistry we have now developed an environmentally benign and novel approach for the synthesis of 4-(substituted benzylidene)- 2-phenyl-1-(5-(pyridin-4-yl) 1, 3, 4-thiadiazol-2-yl)-1H-imidazol-5(4H)-one. The title compounds were prepared by the reaction of 5-(pyridin-4-yl)-1, 3, 4-thiadiazol-2-amine with various 4-(substituted benzylidene)-2-phenyloxazol-5(4H)-one by using modified domestic microwave oven. The structure of these compounds was assigned on the basis of elemental analysis, IR, 1H NMR spectral data. The compounds showed significant antibacterial activity against B. subtilis , S. aureus (gram-positive) and E.coli (gram-negative) bacteria and antifungal activity against C. albicans and A. niger fungi.

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