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Paper Details

Synthesis and antimicrobial studies of biologically potential Mannich bases of 5-chloro-2-methoxy benzamide derived from sulphonamides

Deepak Khare*, Sheela Joshi and Dheeraj Mandloi

Journal Title:Journal of Chemical, Biological and physical sciences

Mannich reaction is the key step in the synthesis of numerous pharmaceutical and natural products. A large number of Mannich bases continue to be synthesized to explore their biological potential, there is an additional effort to look for variations in the execution of Mannich reaction. Due to active hydrogen, 5-chloro-2-methoxy benzamide (substrate) undergoes Mannich reaction. The pharmacological effectiveness of substrate and sulphonamides prompted us to introduce the sulphonamide moiety into the compound, which may furnish products with enhanced therapeutic potency. The Mannich bases of this compound have proved to be more effective and less toxic antibacterial agent. The purity of formed novel Mannich bases were checked by thin layer chromatography and the chemical structure of newly synthesized Mannich bases were confirmed using elemental analyses, UV, IR and 1H NMR spectroscopy. All synthesized Mannich bases were evaluated for their antibacterial activity towards pathogenic Gram-negative bacteria. The results were statistically analyzed, meanwhile, an excellent antibacterial outcome were obtained against the pathogens under research and found to be low toxic as ascertained by LD50 test.