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Paper Details

Synthesis and antibacterial activity of some synthetic compounds derived from sulphanilamide and 6 ethyl benzene- 1, 3 diol

Shipra Baluja1*, Ashish Patel1 and Sumitra Chanda2

Journal Title:Journal of Chemical, Biological and physical sciences
Abstract


Schiff bases derived from sulphanilamide, and 6 ethyl benzene-1,3 diol were screened for antibacterial activity against various bacterial strains. Extracts of these compounds were evaluated on 5 strains i.e. E.coli, Pseudomonas aeruginosa, Proteus vulgaris, Klebsiella pneumoniae and Staphylococcus aureus. The antibacterial activity was evaluated using the Agar Ditch method. The Schiff bases synthesized were 1) 4-(1-aza-2-phenylvinyl)benzene sulphanilamide [UC1] (2) 4-[1- aza-2- (4-methoxyphenyl) vinyl] benzene sulphanilamide [UC2] (3) 4 [1-aza-2-(4- methylthiophenyl)vinyl] benzene sulfonamide [UC3] (4) 4-[1-aza-2- (4-hydroxy-3-methoxy phenyl)vinyl] benzene sulphanilamide [UC4] (5) 4-[2-aza-1-methyl-2-(4nitro phenyl)vinyl]-6- ethylbenzene-1,3-diol [UV1] (6) 4-[2-aza-2-(3,4-dimethyl phenyl) methylvinyl]-6-ethylbenzene-1,3- diol [UV2] (7) 4-[2-aza-1-methyl-2- (3-nitro phenyl) vinyl]-6-ethylbenzene-1,3-diol [UV3] (8) 4-[2- aza-1-methyl-2- (3-mehtyl phenyl)vinyl]-6-ethylbenzene-1,3-diol [UV4]. The BIOASSAYS were evaluated in one polar and one non polar (i.e., DMF and 1,4 dioxan) solvents. It is found that among UC and UV compounds, UV compounds are better than UC and UV1 and UV3 are the best while 1,4 dioxan solvent proved to be more effective than DMF. It appears that the Schiff base with 6 ethyl benzene-1,3diol as central moiety with nitro aniline as side chain both in meta and para position could be lead antibacterial templates.

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