Preparation and evaluation of Aceclofenac ophthalmic in-situ gels
K. Ravindra Reddy*, M. Ravi Shankar Yadav and P.Sabitha Reddy.
Journal Title:Journal of Chemical, Biological and physical sciences
In?situ gelling systems are viscous polymer?based liquids that exhibit sol?to?gel phase
transition on the ocular surface due to change in a specific physico?chemical parameter like
temperature, ionic strength, or pH. A major problem in ocular therapeutics is the attainment of
optimal drug concentration at the site of action, which is compromised mainly due to pre?corneal loss
resulting in only a small fraction of the drug being ocularly absorbed. The effective dose administered
can be altered by increasing the retention time of medication into the eye by using in situ gel forming
systems, thereby preventing the tear drainage. The present work describes the formulation and
evaluation of an ophthalmic delivery system of an anti?inflammatory drug aceclofenac, based on the
concept of pH triggered in situ gelation. In vitro release studies indicated among the all formulations,
F4 shows better drug release when contacted with STF solution at 8 hrs study period. It shows
antimicrobial, antibacterial and antifungal efficacy with selected microorganisms. These results
demonstrate that the developed system is an alternative to conventional ophthalmic drops, patient
compliance, industrially oriented and economical.