Synthesis of Novel Functionalized Chalcones and their In-vitro Antimalarial Evaluation
Kunwarvir Singh1, Manisha2, Mamta Likhawat3 and Lal Singh2
Journal Title:Journal of Chemical, Biological and physical sciences
Two series of novel chalcones have been synthesized and evaluated for their in-vitro
antimalarial activity against chloroquine sensitive strain of Plasmodium falciparum (NF-54). Of the
14 compounds synthesized, 5 compounds viz, 4f, 5b, 5e, 5f and 5g were found to be most potent
and shown IC50 values in the range 2-9 ?g/mL.