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Paper Details

Synthesis, Characterization and anti-HIV activity of 3-methyl-1h-pyrano [2’, 3’:4, 5] pyrano [3, 2-c] chromene-1, 5, 12-trione

Denish C. Karia*1, Hetal K. Pandya1, Nilesh K. Godvani1 and Anamik K. Shah2

Journal Title:Journal of Chemical, Biological and physical sciences

Substituted 4-hydroxy -2H,5H pyrano (3,2-C) chromene – 2,5 –dione(I) have been prepared by 4-Hydroxy coumarin when treated with phosphorus oxychloride and zinc chloride. (I) on reaction with acetic acid and phosphorous oxychlorideto give 3- acetyl 4-hydroxy -2H,5H pyrano (3,2-C) chromene – 2,5 – dione(II). Which on heating with ethyl acetate and pulverized sodium metal for several hours afforded 4-hydroxy-3-(3-oxobutanoyl)2H,5H pyrano(3,2- c)chromene-2,5-dione (III) . (III)when treated with ethanol and hydrochloric acid afforded to give 3-Methyl-1H-Pyrano[2’,3’:4,5]Pyrano[3,2-c]chromene-1,5,12-trione(IV).Several of similar derivatives were also synthesized. The structures of the synthesized compounds have been assigned on the basis of elemental analyses, IR, NMR and mass spectral studies.