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Paper Details

Microwave assisted improved synthesis and antibacterial activity of some 1-acetyl-3, 5-diaryl- 2 pyrazolines

Jayant P. Singh, Vikash Tiwari, Sumer S. Chundawat, Anju Devpura, Neetu Jaitawat, Mangalshree Dulawat, Shiv S. Dulawat*

Journal Title:Journal of Chemical, Biological and physical sciences

Microwave induced solvent-free solid phase synthesis of 1-acetyl-3,5-diaryl- ?2 pyrazolines has been achieved by the cyclocondensation of substituted chalcones (1a-f) with hydrazine hydrate (2) followed by acetic acid in the presence of alumina under solvent free condition using domestic microwave oven has been described. The process has advantage over conventional methods such as shorter reaction time, higher yield and environmental acceptability. The structures of these compounds were established by elemental analysis and spectral data. All the synthesized compounds were tested for their in vitro antibacterial activity. Some compounds showed significant antibacterial activities.