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Paper Details

Hydrotropes as effective reaction media for the synthesis of metoclopramide hydrochloride

Jagannath Kadam1*, Ajay Patil, Vijay Gangan, Manohar Lokhande2 and Vijay Bhawe

Journal Title:Journal of Chemical, Biological and physical sciences

The paper describes the synthesis of Metoclopramide.HCl (have therapeutic use as Antiemetic drug used to combat nausea and vomiting in chemotherapy and post operative patients) using four different hydrotropes. The effect of various hydrotropes on yield, rate constant and activation energy at various temperatures and concentrations were studied.