Hydrotropes as effective reaction media for the synthesis of metoclopramide hydrochloride
Jagannath Kadam1*, Ajay Patil, Vijay Gangan, Manohar Lokhande2 and Vijay Bhawe
Journal Title:Journal of Chemical, Biological and physical sciences
The paper describes the synthesis of Metoclopramide.HCl (have therapeutic use as Antiemetic drug
used to combat nausea and vomiting in chemotherapy and post operative patients) using four
different hydrotropes. The effect of various hydrotropes on yield, rate constant and activation energy
at various temperatures and concentrations were studied.