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Paper Details

Synthesis of RabeprazoleNa for Hydrotropes as a Reaction Media

Jagannath J Kadam1, Ajay Patil, K.George A 3, Vijay Bhawe and Manohar V Lokhande2

Journal Title:Journal of Chemical, Biological and physical sciences

The paper describes the synthesis of RabeprazoleNa. It is used as an Antiulcerative agent. The molecules in the lattice are held together by intermolecular hydrogen bonds between the NH group of benzimidazole and sulfinyl oxygen atom. The synthesis of RabeprazoleNa. was carried out using four different hydrotropes. The effect of various hydrotropes on yield, rate constant and activation energy at various temperatures and concentrations are studied.