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Paper Details

Histopathological alterations in developing duodenum of Swiss mice, exposed to lead acetate

Ragini Sharma and Isha Barber

Journal Title:Journal of Chemical, Biological and physical sciences

In the present investigation, Swiss albino mice aged 1, 2, and 3 weeks were studied for the effects of lead acetate on duodenum development. The major objective is focused on the histopathological alterations in duodenum due to lead intoxication. Inbred healthy pregnant females were selected and exposed with lead acetate, 16 mg/animal (533 mg/kg BW) during gestation and lactation through canula. At 1, 7, 14 and 21 day of birth, litters were sacrificed, and their gastrointestinal tracts were fixed. Duodenum was evaluated for the developmental changes and histopathological alterations. Our results suggest that early life exposure may induce changes that will become apparent much later in life. Pups from lead exposed mothers, resulted changes in their developing duodenum and these changes were age related. With the advancing age of pups, the magnitude of damage in developing duodenum was increased. It is concluded that lead is an important toxicant which cause marked changes in duodenal cell proliferation and differentiation during postnatal period.