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Paper Details

The Evaluation of Combine Drug Action of Codeine as a Supplementary Drug with Biginelli Dihydropyrimidinone Compounds

Deepak M. Nagrik, bDamodar M.Ambhore,cShrikant S.Patil,bJanakiram B.Devhade

Journal Title:Journal of Chemical, Biological and physical sciences

Dihydropyrimidinones (DHPMs) were synthesized by the three component Biginelli reaction which includes the condensation of aldehyde, ?-ketoester and urea. Codeine was used as the supplementary drug in combination of the resultant Biginelli compounds for biological screening. Interesting results were obtained in accordance with the principle of Synergism. It was observed that, synthesized Dihydropyrimidinones (DHPMs) and the supplementary drug, Codeine worked together to produce results which were not independently obtainable