Synthesis, Structural Elucidation and Antimicrobial Activities of Some Novel Macrocyclic Complexes of Ni (II) Having thiaaza Potential Donors in 18-24 Membered Rings
Vivek G. Dave and Piyush J. Vyas*.
Journal Title:Journal of Chemical, Biological and physical sciences
Macrocyclic complexes of Ni(II) having N2S2 potential donors in 18-24 membered rings, of the general
formula: Ni(L1-5)X2, Where X=Cl-,CH3COO-,NO3- and L(1-5) is Macrocyclic ligands have been synthesized
from the reaction of Nickel(II) salt, Dicarboxylic acids and p-aminothiophenol in 1:2:2 moler ratio in
methanol. These complexes have been characterized by elemental analysis, molar conductance, molecular
weight determination, IR spectra, reflectance spectra, thermo gravimetric analysis and magnetic
measurements. Molecular weight determination of these complexes indicates their monomeric nature.
Octahedral structure has been proposed on the basis of Spectrul data, magnetic data, Reflectance spectra,
and Magnetic measurements. Two sulphur atoms and two nitrogen atoms of the macrocyclic ring
coordinate to the central nickel ion in the square planar form in unidentate behavior. Antimicrobial
activities of these complexes have been studied by screening them against fungi, such as Aspergillus
flavus, Fusarium oxysporum, Trichoderma harzianum, and bacteria, such as Salmonella typhi and Bacillus
subtili. Thise macrocyclic complexes were found to be more fungitoxic and antibacterial than bavestin and
streptomycin taking as a standered.