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Paper Details

Synthesis and Characterization of Some New Oxygen Containing Heterocyclic Compounds

Disha Tilala1*,Vishwa Dhinoja2, Hetal Pandya3 and Denish Karia3

Journal Title:Journal of Chemical, Biological and physical sciences

Coumarins have attracted intense interest in recent years because of their diverse pharmacological applications which depends upon the substitution of coumarin. In recent work 4-hydroxy-2Hchromen- 2-one (I) have been prepared by phenol when treated with phosphorus oxychloride and zinc chloride. (I) on further reaction with phosphorus oxychloride and zinc chloride give 4-hydroxy-2- methylenepyrano [3, 2-c] chromen-5(2H)-one (II). Both (I) and (II) when substituted at position-3 are explored for many kinds of biological activity1,2. For this substitution, reaction of (II) has been carried out with acetic acid and phosphorus oxychloride to produce 4-hydroxy-3-methyl-2-methylenepyrano [3, 2-c] chromen-5(2H)-one (III). Reaction of (III) with ethyl acetate and pulverized sodium gives 4- hydroxy-3-(3-oxobutyanoyl) pyrano [3, 2-c] chromen-2, 5-dione (IV). Synthesized compounds have been characterized by UV, IR and NMR.