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Paper Details

Synthesis and Biological Screening of Novel Heterocyclic Compounds

Tarunkumar M. Patel and *A.M Patel

Journal Title:Journal of Chemical, Biological and physical sciences

4-(1H-naphtho[1,8-de] [1,2,3]triazin-1-ylsulfonyl)-N-arylidene aniline (2a-e) was synthesised by a facile condensation of aromatic aldehydes with 4-(1H-naphtho[1,8-de] [1,2,3] triazin-1-ylsulfonyl)aniline (1) in good yield. Cyclo condensation of compounds (2a-e) with Succinic anhydride yields 1-(4-(1H-naphtho[1,8- de][1,2,3]triazin-1-yl sulfonyl)phenyl)-5-oxo-2-arylpyrrolidine-3-carboxylic acid (3a-e). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.