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Paper Details

Anti-Inflammatory and Analgesic Investigations on Fruit Extract of Nothapodytes Nimmoniana (J. Graham) Mabberly

1Pooja Sharma, 2Priya S Thuluvath, and 3Ajay Sharma*

Journal Title:Journal of Chemical, Biological and physical sciences
Abstract


The present study was designed to investigate comparative anti-inflammatory and analgesic activity of ethanolic fruit extract of Nothapodytes nimmoniana (EFEN). N. nimmoniana contains camptothecin, an anticancer drug, regarded as one of the most promising drug of twenty first century. Anti-inflammatory activity of EFEN was performed by using carrageenan induced paw edema in rats. The extract showed dose-dependent inhibition of paw volume and the maximum percent inhibition was found at the dose of 200 mg/kg (75.79%). The EFEN was effective in both first and second phase of inflammation. Analgesic activity was evaluated for its central and peripheral pharmacological actions in rats and mice. It is expected that EFEN might suppress the formation of prostaglandins and bradykinin or antagonize the action of these substances and thus exerts its peripheral analgesic activity in Randall-Selitto assay and acetic acid induced writhing test. The EFEN significantly increased the reaction time in hot plate and tail flick test, suggesting its central analgesic activity.

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