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Paper Details

A Study Showing the Ameliorative Potential of Trans- Resveratrol, ?- Lipoic Acid and Vitamin E on Endosulfan Induced Alterations in the ATPase in Olfactory Lobe of Male Swiss Albino Mice

Preeti Singh1* and Habiba Bano2

Journal Title:Journal of Chemical, Biological and physical sciences

Brain is profoundly vulnerable to oxidative damage on exposure to certain hazardous substances. Endosulfan, an organochlorine pesticide, is a known, strong neurotoxin in animals as well as in mammals including human beings. The present study aimed to study hazardous impacts of endosulfan on olfactory system, which play a major role in analyzing and perceiving the sense of smell, choice of mate, food localization etc. ATPase, the biomarker of present investigation, is a sympathetic neurotransmitter involved in brain function, sensory perception, and nervous system control of muscles and organs. The deleterious effects caused by endosulfan have been linked to its ability in alterations of ATPase levels. Hence, there is an urgent need to establish a counter policy by means of food regime which can check oxidative stress caused as a result of environmental stressors. This study has been designed to employ antioxidants like resveratrol, alpha lipoic acid and vitamin E as potential therapeutic agents in counterbalancing negative health hazards of endosulfan on the normal functioning of brain. The study was divided into ten groups in which olive oil was given as a vehicle in control group, while endosulfan administered at 2.45 mg/kg/bodyweight/day for 15 days served as an experimental group. Other groups constituted of antioxidant treatment groups and antioxidants pre treatment groups exposed to endosulfan. Altered ATPase histoenzymological profile was observed in different layers of olfactory lobe in endosulfan intoxicated mice, while antioxidant pretreatment groups were able to render protection to some extent as compared to that of control. The findings of present study suggest the inherent potential of antioxidants against endosulfan induced neurotoxicity in the olfactory lobe of mice.