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Paper Details

The Effects of Ethanol Extract of Allium SativumLeaves on Aspartate Aminotransferase, Alanine Aminotransferase and Alkaline Phosphatase in Albino Rats

Oko, M.O.*1, Anyim, C.2, Nworie, O.2, Agah, M.V.2 and Okoli, C.S.

Journal Title:Journal of Chemical, Biological and physical sciences

The effects of ethanol extract of Allium sativumon aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities in albino rats were investigated by spectrophotometeric methods. Sixteen albino rats were divided into four groups (A, B, C, and D) of four animals in each group. Ethanol extract of Allium sativum was administered through oral intubation at the doses of 200 mg/kg, 400 mg/kg, 600 mg/kg and 0mg/kg to the animals in groups A, B, C, and D respectively for fourteen days. Blood samples were collected of the fifteenth day following the last day of administration. The aspartate aminotransferase activities (?/l) recorded 0.750.03, 0.930.06, 1.380.05 and 0.730.02 for the animals in groups A, B, C and D respectively with corresponding alanine aminotransferase activities (?/l) as 0.450.03, 0.760.02, 1.350.04 and 8.510.02. The alkaline phosphatase activities also recorded 13.340.12, 14.640.11, 19.210.07 and 8.510.03 respectively. There were significant (P