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Paper Details

Clinical Conundrums in Ovarian Cancer – A Genetic and Molecular Based Approach – Importance of Personalized Standard-of-care Therapy

Clinical Conundrums in Ovarian Cancer – A Genetic and Molecular Based Approach – Importance of Personalized Standard-of-care Therapy

PK Prem Ravi Varma

Journal Title:Acta Scientific Cancer Biology
Abstract


Epithelial ovarian cancer is the most lethal gynecological malignancy. It can be divided into five main histological subtypes: high grade serous, endometrioid, clear cell, mucinous and low grade serous. These histological subtypes are distinct disease entities at the clinical and molecular level. There is significant genetic heterogeneity in ovarian cancer, particularly within the high grade serous subtype. This subtype of ovarian cancer has been the focus of much research effort to date, revealing molecular subgroups at both the genomic and transcriptomic level that have clinical implications. Therefore stratifying ovarian cancer patients based on the un-derlying biology remains in its infancy. This article summarizes the molecular changes that characterize the five main ovarian cancer subtypes and highlight potential opportunities for targeted therapeutic intervention and outline priorities for future research.