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Paper Details

A Tale of Two Leukemias

A Tale of Two Leukemias

Sajjad A Bhatti and Abdulraheem Yacoub

Journal Title:Acta Scientific Cancer Biology
Abstract


Chronic lymphocytic leukemia (CLL) is the most common adult leukemia [1], characterized by the accumulation of mature but functionally incompetent CD5+ monoclonal B cells. Chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm charac-terized by a reciprocal translocation between chromosomes 9 and 22, leading to BCR-ABL1 fusion gene with constitutive tyrosine kinase activity resulting in dysregulated and uncontrolled proliferation of granulocytes.