A Review on Mevasatin- An Anticholesterol Drug
N Harsha1, S Subbarao2, V Sridevi2*, MVVChandana Lakshmi and T Kanthikiran
Journal Title:Journal of Chemical, Biological and physical sciences
Hypercholesterolemia is considered an importantrisk factor in coronary
artery disease. Thus the possibilityof controlling de novo synthesis of
endogenouscholesterol, which is nearly two-thirds of total body cholesterol,represents
an effective way of lowering plasmacholesterol levels. Statins, fungal secondary
metabolites,selectively inhibit hydroxymethylglutaryl-coenzyme A(HMG-CoA)
reductase, the first enzyme in cholesterolbiosynthesis. The mechanism involved in
controllingplasma cholesterol levels is the reversible inhibition ofHMG-CoA reductase
by statins, related to the structuralsimilarity of the acid form of the statins to HMGCoA,
the natural substrate of the enzymatic reaction. Currentlythere are five statins in
clinical use. Lovastatin and pravastatinmevastatin are natural statins of fungal origin.
This review deals with the chemistry, mechanism for hmg-coareductase inhibition,
biosynthesis and biotransformation, production and applications of mevastatin.