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Paper Details

Computation and Modeling of the Flux of Gamma Globulin Molecules onto Titanium Surface

P. A. Ekwumemgbo1*,J. A. Kagbu1, A. J. Nok2 and K. I. Omoniyi1

Journal Title:Journal of Chemical, Biological and physical sciences

Titanium (Ti) is widely employed for various biomedical applications due to its biocompatibility. Studies of ?-globulin adsorption onto Ti are important for the development of biocompatible devices. This work examines the rate of adsorption of ?- globulin onto Ti surface. The plot of ?-globulinadsorption onto Ti versus time shows that the initial ?-globulinadsorption increased linearly with time with the rate constant obtained 0.032min-1 while the correlation coefficient (R2)is 0.9999. The experimental adsorption rate is limited by the availability of ?-globulin molecules at the adsorbing surface, resulting in a situation in which, most ?-globulin molecule that collides with the surface sticks to it. In order to predict the factors that determine the rate of adsorption, the flux of ?-globulin molecules onto Ti surface was computed by developing a model similar to implantation of Ti into the body for the transport-limited of ?-globulin adsorption onto Ti from flowing ?-globulin solution. It was deduced that the rate of this adsorption is determined by the wall shear rate, the diffusivity of ?-globulin and the bulk amount of ?- globulin solution. An adsorption model was developed in order to seek the factors that determine the intrinsic (qualitative) adsorption and desorption rate constants. The experimental adsorption data was likened to a simple ?-globulin adsorption model, which comprises of adsorption and desorption processes. The model incorporated the rate of diffusion through the boundary (unstirred) layer of constant thickness by solving for the Fick's law. It was deduced that the intrinsic adsorption and desorption rate constants of ?- globulin could be defined as (empirical) exponential functions of the amount of ?-globulin onto Ti surface.