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Paper Details

BF3- Etherate Mediated Cyclization Reaction of Cholecalceferol

Sultanat* and M.Mushfiq

Journal Title:Journal of Chemical, Biological and physical sciences
Abstract


We have investigated the cyclisation behaviour of sterols such as cholecalciferol (1), cholecalciferol acetate (2) and cholecalciferol chloride (3) with BF3 etherate using Diels- Alder reaction which provides direct access to the cyclized derivatives 4-6 in good to excellent yield. It presents a novel intramolecular reaction catalysed by boron trifluoride etherate and broadens the scope of application.The easy work-up, higher yields and shorter reaction time is the advantages of the method presented here.

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