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Paper Details

Effect of Chaotropic Agents on Gram Positive and Gram Negative Bacteria

1Ananda Vardhan Hebbani, 1Roopasri Ranganatha, 1Radhika Karal Nair, 1Divya Puttaswamappa, and 2John Barnabas

Journal Title:Journal of Chemical, Biological and physical sciences

Inorganic and organic chaotropic agents were analyzed for their effects on pathogenic bacteria, namely Staphylococcus aureus ATCC 25923 a Gram positive species and Escherichia coli ATCC 25922 a Gram negative species, with an objective to understand these effects on the variable membrane configurations and permeability properties that exists among their cell walls and membranes respectively. The studies revealed the extent of bacterial lysis that amplified with rise in concentrations of chaotropic agents, in a time dependent mode. Furthermore, findings proved that, the inorganic chaotropic agents had shown a higher efficacy against Gram-positive species while the organic chaotropic agents demonstrated a higher efficacy against Gramnegative species. The findings revealed, specific type of chaotropic agents affects specific Gram nature of bacteria. This paves way for dimensional understanding of the susceptibility of biological membranes towards specific chaotropic agents.