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Paper Details

An Insilico Investigation on Serpinc1 from Homo Sapiens

Maheswara Reddy Mallu*, Srinivasa Reddy Ronda and Sandeep Vemula

Journal Title:Journal of Chemical, Biological and physical sciences
Abstract


The SERPINC1 gene belongs to a family of genes called SERPIN (serine (or cysteine) proteinase inhibitors). The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. This is an attempt to know the molecular information of SERPINC1 gene & its coded protein molecule like composition, primers, peptide coded by gene, protein structure and the posttranslational modifications. The exploration of SERPINC1 gene reveals that, the SERPINC1 is a 1599 base pair pyramidine rich sequence with a molecular weight of 971.839 KDa (dsDNA). It has seven ORFs & 8 restriction sites for cloning. The primary structure is stable and slightly acidic in nature. Secondary structure is mainly composed of random coils, alpha helix beta sheet and betaturn. The gene contains both left & right primers and a Hybridoligo probe. Posttranslational modification studies predicted 28 phosphorylation sites (for Serine, Threonine & Tyrosine), 4 net NGlycosylation sites in the encoded protein of SERPINC1.

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