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Paper Details

Body weight and length in neonates of Swiss mice exposed to lead and vitamins

Ragini Sharma, Khushbu Panwar*and Isha Barber

Journal Title:Journal of Chemical, Biological and physical sciences

The major concern about lead exposure during pregnancy lies in the possibility of adverse effects on the development of fetus. The present study was accomplished to evaluate the lead toxicity on body weight and length in lead exposed pups after birth during neonatal period. Mice neonates during developmental period from birth to 21st day of weaning on specific days viz. 1, 7, 14 and 21st day were examined to record the changes in body weights and crown to rump length. Lead acetate was administered via oral gavaging at 266 mg/kg/bodyweight, 533 mg/kg/bodyweight and 1066 mg/kg/bodyweight to pregnant Swiss mice from 10th day of gestation to 21st day of lactation. Correspondingly vitamin C and vitamin E were administered at 166 mg/kg/bodyweight and 133 mg/kg/bodyweight alone and in combination with lead. Lead suppresses the body weights and crown to rump length of neonates significantly in all experimental groups. Interestingly significant increase was detected in body weights and crown to rump length in vitamin C and E treated neonates. However the antioxidants treatment along with lead did not balanced the altered growth status of neonates at different postnatal stages during neonatal life.