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Paper Details

Novel Spiro Oxazoles Containing Triazolothiadiazines, Thiadiazines and Thiazines - Synthesis, Characterization and Biological evaluation

Vijay V. Dabholkar*, Abhishek Karekar, N. B. Shinde & Prem Naik

Journal Title:Journal of Chemical, Biological and physical sciences

Abstract:A mixture of compound (1) and Glycine were refluxed in presence of acidic medium to yield compound (2) which further under bromination to give compound (3) Which on further treatment with Substituted 2-aminothiophenols, Substituted Thiocarbohydrazones and Substituted triazoles yields the respective benzothiazines, Thiadiazines, triazolo-thiadiazines, derivative(4a-6c). The structures of the products were confirmed by IR, 1H, 13C NMR and elemental analysis. Representative samples were screened for their anti-microbial activity against gramnegative bacteria E.coli and B.Substilus and gram-positive bacteria S. aureus, and S.typhi.