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Paper Details

Synthesis and Biological Studies of Co(II), Ni(II) and Cu(II) Complexes with ONNO Donor Coumarin Schiff Bases

Sangamesh A. Patil1*, ChetanT.P1, and Prema S. Badami2

Journal Title:Journal of Chemical, Biological and physical sciences

The Schiff bases and their complexes of Co(II), Ni(II) and Cu(II) have been synthesized from 6-formyl-7,8-dihydroxy-4-methylcoumarin with o-phenylene diamine/ethylenediamine. The Schiff bases and their metal complexes structurally characterized based on IR, NMR, UV-visible, ESR, magnetic, thermal, and mass and ESI-MS studies. The complexes are soluble in DMF and DMSO and their molar conductance values indicate that complexes are non-electrolytic in nature. Elemental analysis reveals ML.2H2O [M = Co(II), Ni(II) and Cu(II)] stoichiometry, where L stands for a doubly deprotonated ligand. The spectroscopic studies suggest the octahedral geometry. In which the lingands co-ordinates through azomethine nitrogen and phenolic oxygen via deprotonation. Thermal studies suggest co-ordination of water molecule to the metal ion. The Schiff bases and their metal complexes have been screened for their antibacterial activity against the bacterial species, Escherichia coli, Pseudomonas auregenosa, klebsiella and Staphylococcus aureus, antifungal activity against the fungal species, Penicillium chrysogenum and Aspergillus niger. The anthelmintic activity of the synthesized compounds carried out using an adult Indian earthworm, Pheretima posthuma, due to its anatomical and physiological resemblance with the intestinal roundworm parasite of human beings.