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Paper Details

Synthesis and antimicrobial screening of some new N1-citralidene hydrazido quinolin- 2(1H)-one derivatives

Pravina B. Piste*1, Shubhangi M. Kanase1, Surekha B. Shevale1 and Maruti S. Kanase2

Journal Title:Journal of Chemical, Biological and physical sciences
Abstract


Synthesis of desired compound involved carbethoxymethylation of 4- methyl quinolin-2(1H)-ones (III a-c) to form N1-carbethoxy methyl quinolin-2(1H)- ones (IVa-c) followed by hydrazine hydrate affords the corresponding N1-acetyl hydrazido 4-methyl-quinolin-2(1H)-ones (Va-c). The reaction of (Va-c) with citral yields corresponding N1-citralidene acetyl hydrazido-4-methyl quinolin-2(1H)-ones (VIa-c). The structure of the synthesized compounds have been established on the basis of IR, NMR and Mass studies. The synthesized compounds (Va-c) and (VIa-c) have been screened for their antimicrobial activities and found to possess significant antimicrobial activities.

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