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Paper Details

Synthesis and in-vitro Biological Evaluation of a Novel Series of 4-(Substituted)-5-Methyl-2-Phenyl-1, 2-Dihydro-3H-Pyrazol-3-One as Antioxidant

Shweta S. Bule*, M. R. Kumbhare, P.R. Dighe,

Journal Title:Journal of Chemical, Biological and physical sciences
Abstract


A novel series of 4-(substituted)- 5-methyl-2-phenyl-1,2- dihydro-3H-pyrazol-3-one (5a-n) were synthesized by reacting various substituted R-NH2 with 5-methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one in the presence of formaldehyde. Structures of all new synthesized compounds were characterized on the basis of spectral data (IR, 1H NMR and 13C NMR). The title compounds were screened for in-vitro antioxidant activity. Among the 7 prepared compounds, Compounds 5a , 5b, 5c exhibited significant antioxidant activity in model of 1,1-diphenyl- 2- picryl hydrazyl , Nitric Oxide , Hydrogen peroxide and were compared with Ascorbic acid as a standard drug.

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