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Paper Details

A Comparative Study of Antimicrobial and DNA Clevage Activity of Metal(II) Complexes of Coumarin Derivatives

Disha Tilala1*, Manish Solanki2, Denish Karia3

Journal Title:Journal of Chemical, Biological and physical sciences
Abstract


New transition metal complexes of the composition, M[L(H2O)]2, where M= Fe(II), Ni(II), Co(II) and Cu(II); L= ligands prepared from 3-acetyl-4-hydroxy-8- methylpyrano[3,2-c]chromene-2,5-dione(LI) and 4-hydroxy-8-methyl-3-(3-oxobutyanoyl) pyrano [3,2-c]chromen-2,5-dione (LII), were synthesized and characterized by elemental analyser, conductivity measurement, IR, UV-Vis. and 1H-NMR spectral techniques. The low conductance data provide evidence for the non-ionic nature of the complexes. The antimicrobial activities of the ligands and their complexes have been studied by screening the compounds against the bacteria E. coli and B. megaterium and also the fungi C. albicans and A. niger. The data indicate that most of the metal complexes have higher antimicrobial activity than the free ligands. The DNA cleavage experiments, performed using gel electrophoresis with the corresponding metal complexes in the presence of H2O2 showed good results.

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