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Paper Details

Microwave Assisted Synthesis and Biological Activities of Some ?,?-Unsaturated Cyclohexanone and Their Pyrazoline, Isoxazolines Derivatives

A. Wasi1, Bhupendra Kumar Sharma2 , Ashish Kumar Gupta3 and Kumud Intodia1

Journal Title:Journal of Chemical, Biological and physical sciences

Condensation of cyclohexanone with substituted benzaldehyde in presence of neutral alumina under microwave irradiation affords substituted ?,?? unsaturated cyclohexanone in quantitative yields. Which undergoes cyclization with hydrazines (Phenylhydrazine,2,4-dinitrophenyl hydrazine, semicarbazide and thiosemicarbazide) to afford a series of novel 7-(substituted benzylidene)-3-(substituted phenyl)-2- (substituted)-3, 3a, 4, 5, 6, 7-hexahydro-2H-indazole derivatives. Some new 7- (substituted benzylidene)-3-(substituted phenyl)-3, 3a, 4, 5, 6, 7-hexahydrobenzo[c] isoxazole derivatives were also synthesized in quantitative yields by cyclococondensation of substituted ?, ?? unsaturated cyclohexanone with hydroxylamine hydrochloride under microwave irradiation. The structures of all the compounds were confirmed by their analytical and spectral data. All the synthesized compounds were screened for antibacterial and antifungal activity. Almost all compounds have shown excellent activity against some Multi Drug Resistant bacteria.