Treatment Strategies against Female Reproductive Lead Toxicity: A Review
Ragini Sharma and Khushbu Panwar*
Journal Title:Journal of Chemical, Biological and physical sciences
Environmental endocrine disruptors have been at the heart of discussion
about chemicals and their effects on fertility, but the focus on the heavy metals and
the role of antioxidants during developing stages has been largely overlooked. Lead
induced oxidative stress contributes to the pathogenesis of lead poisoning by
disrupting the delicate pro oxidant or antioxidant balance that exists within
mammalian cells. The role of chelating agents in lead poisoning is controversial.
Most of the chelating agents tend to have adverse side effects and the benefits are
transitory. The chelating agents cannot be used during developing stages as this
period is highly sensitive to these agents and chelators have concomitant and
injurious side effects on development. The assumption of oxidative stress as a
mechanism in lead toxicity suggests that antioxidants or vitamins might play a role in
treatment of lead induced toxicity. In the present review methods of screening for
sub-clinical lead poisoning along with dietary treatment and prevention are discussed.