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Paper Details

Potentiometry and Spectrophotometry Studies of Binary Complex of Tripeptide TFA.Leu-Ala-Phe- OH with Cu (II).

Sanjay N. Aher,a,b,*, Supriya S. Aher b, S. D. Rathod a.

Journal Title:Journal of Chemical, Biological and physical sciences

Tripeptide TFA.Leu-Ala-Phe-OH synthesized by using conventional solution phase peptide synthesis strategies. The proton and Cu (II) solution equilibrium investigation of tripeptide binary complex are studied by potentiometric and spectrophotometric measurements in aqueous media. Measurements were carried out at varying temperature and ionic strength conditions. Potentiometric studies performed by using Calvin-Bjerrum titration technique as used by Irving and Rossotti while spectrophotometric measurements performed to determine conditional stability constant (Log Kcond) by Jobs continuous variation method at pH 5.5. Both potentiometric and spectrophotometric data evaluation shows inverse trend with varying temperature and ionic strength conditions on the proton and Cu (II) binary complex stabilities in aqueous media.