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Paper Details

Synthesis, Characterization, Invitro and Insilico Drug Activity of Mixed Ligand Copper (II) Complexes

G.Valli and S.Gayathri

Journal Title:Journal of Chemical, Biological and physical sciences

Copper(II) metal complexes can be derived from O-benzoyl benzoic acid and thiophene-2-aldehydethiosemicarbazone schiffbase and mixed ligand Copper(II) metal complexes have been synthesized and characterized in the light of UV, IR, and ESR spectral studies. The synthesized Copper(II) metal complexes have been screened for their invitro antimicrobial activities by zone of inhibition method against Escherichia coli. Pseudomonas Aeruginosa, Klebsilla Pneumoniae, Staphylococcus Aureus and Staphylococcus Epidermidis and also by insilico approach using Hex4.2 Software and PASS online software. The antimicrobial screening showed that [O-benzoylbenzoicacidato] [Salicylaldehydato] Copper (II) possessed higher activity towards S.Aureus and P.Aeroginosa. The docking score value of Cu (II) complexes showed that [O benzoylbenzoicacidato] [Salicylaldehydato phenyl hydrazonato] Copper (II) possesses highest drug likness property against E.Coli, S.Aureus and S.Epidermis. PASS prediction showed the following activities like Maillard reaction inhibitor activity (94.1%), Phosphatase inhibitor, 3-Hydroxybenzoate 4-monooxygenase inhibitor, Glucose oxidase inhibitor, Interferon alpha agonist and Monodehydroascorbate reductase (NADH) inhibitor activities greater than 80%. Erythropoietin and antiviral (Arbovirus) activities were observed to be greater than 65%.