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Paper Details

Determination of Changes in Antioxidant Status in Hypertension-Induced Congestive Heart Failure Patients

Oladunjoye Z. M1, Akinosun M.O2, Ojure M.A3, Quadri J.A4, Aborishade M .V5

Journal Title:Journal of Chemical, Biological and physical sciences
Abstract


Congestive heart failure is a common end point of many abnormal cardiac conditions. Cardiovascular diseases have been linked with oxidative stress which provides the strongest evidence for the protective role of antioxidants. A high consumption of fruit and vegetables which are good sources of antioxidants has been associated with lower coronary risk. Specifically, there is evidence of reduced coronary risk in population with high blood levels of the antioxidants nutrients, Vitamin C and E. Change in the level of total antioxidant status (TAS), Vitamin A,E, C levels and antioxidant trace metals (Selenium, Zinc, Copper, Manganese) were studied in the plasma of sixty one (61) participants comprising thirty (30) hypertensive subjects without heart failure (HTN) eleven hypertension induced congestive heart failure subjects (CHF)and twenty (20) non hypertensive apparently healthy individuals (Control) using spectrophotometric method, HPLC and atomic absorption spectrometry (AAS) techniques respectively. The age of the subjects ranged between 30 and 79 years. In CHF group, there was significant lower mean plasma levels of TAS and Vitamin C in congestive heart failure compared with controls (p=0.04, p=0.04 respectively). Other parameters were not statistically different. Similarly, HTN group had significantly lower level of TAS compared with controls (p=0.01). On the contrary, Vitamin E level was significantly high in hypertension group (p=0.00). Other antioxidant parameters compared; Vitamin A, Vitamin C, Selenium, Zinc, Copper and Congestive heart failure is a common end point of many abnormal cardiac conditions. Cardiovascular diseases have been linked with oxidative stress which provides the strongest evidence for the protective role of antioxidants. A high consumption of fruit and vegetables which are good sources of antioxidants has been associated with lower coronary risk. Specifically, there is evidence of reduced coronary risk in population with high blood levels of the antioxidants nutrients, Vitamin C and E. Change in the level of total antioxidant status (TAS), Vitamin A,E, C levels and antioxidant trace metals (Selenium, Zinc, Copper, Manganese) were studied in the plasma of sixty one (61) participants comprising thirty (30) hypertensive subjects without heart failure (HTN) eleven hypertension induced congestive heart failure subjects (CHF)and twenty (20) non hypertensive apparently healthy individuals (Control) using spectrophotometric method, HPLC and atomic absorption spectrometry (AAS) techniques respectively. The age of the subjects ranged between 30 and 79 years. In CHF group, there was significant lower mean plasma levels of TAS and Vitamin C in congestive heart failure compared with controls (p=0.04, p=0.04 respectively). Other parameters were not statistically different. Similarly, HTN group had significantly lower level of TAS compared with controls (p=0.01). On the contrary, Vitamin E level was significantly high in hypertension group (p=0.00). Other antioxidant parameters compared; Vitamin A, Vitamin C, Selenium, Zinc, Copper andCongestive heart failure is a common end point of many abnormal cardiac conditions. Cardiovascular diseases have been linked with oxidative stress which provides the strongest evidence for the protective role of antioxidants. A high consumption of fruit and vegetables which are good sources of antioxidants has been associated with lower coronary risk. Specifically, there is evidence of reduced coronary risk in population with high blood levels of the antioxidants nutrients, Vitamin C and E. Change in the level of total antioxidant status (TAS), Vitamin A,E, C levels and antioxidant trace metals (Selenium, Zinc, Copper, Manganese) were studied in the plasma of sixty one (61) participants comprising thirty (30) hypertensive subjects without heart failure (HTN) eleven hypertension induced congestive heart failure subjects (CHF)and twenty (20) non hypertensive apparently healthy individuals (Control) using spectrophotometric method, HPLC and atomic absorption spectrometry (AAS) techniques respectively. The age of the subjects ranged between 30 and 79 years. In CHF group, there was significant lower mean plasma levels of TAS and Vitamin C in congestive heart failure compared with controls (p=0.04, p=0.04 respectively). Other parameters were not statistically different. Similarly, HTN group had significantly lower level of TAS compared with controls (p=0.01). On the contrary, Vitamin E level was significantly high in hypertension group (p=0.00). Other antioxidant parameters compared; Vitamin A, Vitamin C, Selenium, Zinc, Copper andManganese were statistically not significant. Plasma levels of vitamin C was significantly lower in HTN compared with CHF (p=0.049). No significant difference was observed in other parameters. Significant negative correlation between BMI and TAS, (r = -0.47, p

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