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Paper Details

HIV-1 Integrase Inhibitors: Update and Perspectives

Pritam N. Dube*

Journal Title:Journal of Chemical, Biological and physical sciences

HIV replication requires the insertion of the viral genome inside the nuclear genome of infected cells through a recombination process catalyzed by the virus-encoded enzyme, integrase. HIV integrase has recently been recognized as a reachable antiviral target following the promising results of integrase inhibitors in clinical trials. The present review focuses on the recent advances in understanding the cellular mechanisms of HIV integration and the sites of actions of inhibitors. It also provides an extensive list of the known mutations that have been characterized for HIV-1 integrase with their impact on integrase activity, viral replication and response to anti-integrase drugs. Novel rational approaches for inhibiting HIV integration are also discussed, as well as the two integrase inhibitors in clinical trials and other selected inhibitors in development.