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Paper Details

Frecuencia de potenciales interacciones medicamentosas entre antirretrovirales y otros grupos farmacolgicos en pacientes colombianos

Jorge Enrique Machado Alba, Cristhian David Morales Plaza, Valentina Hoyos Soto

Journal Title:Investigaciones ANDINA

Objectiv: determine the prevalence of potential risk drug interactions between antiretroviral and other drugs in Colombian patients with HIV/AIDS. Materials and methods: cross-sectional study who took the prescription drugs a population database of 6.2 million users from May 1 to July 31, 2012. To identify potential interactions, we sought dispensing antiretrovirals: Nucleoside Reverse Transcriptase Inhibitors, Non-Nucleoside Inhibitors of Reverse Transcriptase (NNRTIs), Protease Inhibitors (PIs), integrase inhibitors, CCR5 antagonists and fusion inhibitors with other risk drugs because their ineffectiveness or toxicity. Analysis by SPSS 21.0. Results: 968 patients were obtained, mostly men (n = 844, 87.2%), mean age 41.610.5 years (range: 3-75 years) and male:female ratio of 5.8:1, from 25 cities. In total we found 49 associations of risk; the IPs being involved in 40 cases. The most common interaction was between IPs and statins (OR: 29.5, 95%CI:14,837-58, 785, p