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Synthesis and Characterization of Some Mixed Ligand Metal Complexes of Anti-Inflammatory Drugs

Synthesis and Characterization of Some Mixed Ligand Metal Complexes of Anti-Inflammatory Drugs

I. Musa, B. El-yaqub, A. O. Raji, A. A. Aliyu

Journal Title:Science View Journal
Abstract


Twelve metal complexes derived from ibuprofen, naproxen and paracetamol were synthesized using the following metal ions: Zn(II), Ni(II), Fe(II), Co(II), Cr(II) and Mn(II). Metallo-ibuprofen, paracetamol and naproxen complexes were investigated by spectral and physical techniques. The complexes were characterized by melting point, solubility, conductivity measurement, elemental analysis, UV-Visible, infrared and H1NMRspectroscopy. The complexes have higher melting point than their free ligands and the lowervalue of conductivity test showed that the complexes are non-electrolyte in nature. The spectroscopic data proposed that naproxen coordinated through oxygen of the carbonyl. Paracetamol ligands behaved as a neutral bi-dentate ligand coordinated to the metal ions via the lone pair of electrons of the nitrogen and carbonyl-O atoms of the amide group. On the other hand, ibuprofen ligand coordinated to the metal ions via the deprotonated carboxylate-O atom. From the micro-analytical data, the stoichiometry of the complexes reacts with Mn(II), Co(II), Fe(II) and Cu(II) by molar ratios (2:1) (drug: metal ion). All complexes were proposed to be octahedral geometry with ligands acting as bi-dentate.