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Paper Details

18F-FDG PET/CT in Identifying Primary Site in Patients with Neck Secondaries: A Cross Sectional Study

18F-FDG PET/CT in Identifying Primary Site in Patients with Neck Secondaries: A Cross Sectional Study

Darwin Kaushal, Suresh Chandra Sharma, Rakesh Kumar, Bidhu Kalyan Mohanti, Ashu Seith Bhalla and Nithin Prakasan Nair

Journal Title:Acta Scientific Otolaryngology
Abstract


Purpose: The detection of the primary site in patients with carcinoma unknown primary neck is always a challenge. This study was conducted to assess the role of 18F-FDG PET/CT in detecting the primary in patients with neck secondaries. This study also aimed to compare its diagnostic sensitivity with computed tomography and triple endoscopy.Materials and Methods: We prospectively evaluated thirty two patients of carcinoma of unknown primary who presented with cervical lymphadenopathy. Inclusion criteria were all patients who had a fine-needle aspiration of cervical lymph node suggestive of squamous cell carcinoma without clinically detectable primary site. We did a clinical and radiological evaluation for all patients. All patients were subjected to further assessment by a triple endoscopy and 18F-FDG PET/CT. Following 18F-FDG PET/CT, we took a biopsy from the suspicious site in all patients. The biopsy reports were collected.Results: The primary detection rate was 18.8%. With the help of PET CT, biopsy confirmed primary site was detected in 6 patients. The sensitivity, specificity, positive predictive value, negative predictive value of PET-CT were 100%, 34.6%, 26.1%, 100% respec-tively. Conclusion: 18F-FDG PET/CT has higher sensitivity, detection rate and negative predictive value as compared to computed tomog-raphy and triple endoscopy