Polymorphous Low-Grade Adenocarcinoma: A Case Report
Isadora Kamila Oliveira Silva1, Marina Siqueira Teixeira1, Victoria Dias de Miranda Paula Barroso1, Alessandra Oliveira Ferrari Gomes2, Silvia Paula de Oliveira3 and Luisa Aguirre Buexm
Journal Title:Acta Scientific Otolaryngology
Polymorphous low-grade adenocarcinoma (PLGA) is a malignant neoplasm featuring low aggressiveness and almost exclusively originated from minor salivary glands. A case of PLGA is reported in an 81-year-old female patient who attended the stomatology clinic reporting an increase in volume of palate. Intraoral examination revealed a tumor on the right posterior palate, hard in consis-tency and painless. Radiographic examination didn't reveal abnormalities. An incisional biopsy was performed with histopathologic diagnosis of salivary gland malignant neoplasm. Immunohistochemically the tumor cells were positive for EMA, CEA, p63, CK14, vimentin, S-100 protein and Ki-67 (< 1%), but negative for smooth muscle actin and GFAP. The patient underwent surgery with tumor-free margins, confirming PLGA. An obturator prosthesis was placed after surgery. PLGA is a slow-growing, distinct, uncommon neoplasm of the minor salivary glands. Because it is characterized by a diverse morphologic pattern that resembles adenoid cystic carcinoma or pleomorphic adenoma, the initial diagnosis is usually inconclusive.