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Paper Details

HDAC11 Enzyme: Multifaceted Roles and New Avenues in Cancer Therapy

HDAC11 Enzyme: Multifaceted Roles and New Avenues in Cancer Therapy

Vasundhara Sharma

Journal Title:Acta Scientific Cancer Biology
Abstract


Histone deacetylases (HDACs) are enzymatically super-active in various malignancies, deacetylating lysine (K) moieties of amino acids, and altering the functional properties of a plethora of his-tone and non-histone proteins. Histone deacetylase 11 (HDAC11), a novel class IV HDAC, is a newly discovered HDAC, regulating mul-tiple physiological programs in a wide variety of normal tissues and cancer cells. Enzymatically, it is a modest deacetylase as well as a deacylase of target proteins.