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Paper Details

Clinical Implications in Understanding Prostate Cancer Biology: From Androgen Receptor to Molecular Target Therapy in Metastatic Castration Resistant Prostate Cancer

Clinical Implications in Understanding Prostate Cancer Biology: From Androgen Receptor to Molecular Target Therapy in Metastatic Castration Resistant Prostate Cancer

Eliza Dalsasso Ricardo*, Angel AT Uchiyama, Denis S Shimba and Ariel G Khan

Journal Title:Acta Scientific Cancer Biology
Abstract


Prostate cancer is one of the most common malignancies in the world. For a long time, the cornerstone of treatment for advanced disease has been the manipulation of hormonal pathway of testosterone since is well stablished that androgen receptor regulates prostate growth, differentiation and apoptosis in regular and cancer cells. However, during the treatment of metastatic disease with androgen deprivation therapy resistance mechanisms appear, which led to the development of new treatments, such as second-generation anti-androgens-like (such as enzalutamide, apalutamide and darolutamide), and abiraterone acetate. In addition to the development of this new antiandrogens the deeper knowledge about DNA damage repair and their pathways such as direct reversal, mismatch repair, base excision repair, homologous recombination and the non-homologous end joining, resulted in new opportuni-ties of treatment. Recently, PARP inhibitors have showed their efficacy in the treatment of advanced prostate cancer. Therefore, the aim of this article is to review the current knowledge about cancer prostate biology and its clinical implications.