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Paper Details

Networking Between Cell Biology, Genetics and Personalized Management: Focusing on Circulating Tumor Cells and D1853N Polymorphism

Networking Between Cell Biology, Genetics and Personalized Management: Focusing on Circulating Tumor Cells and D1853N Polymorphism

Parvin Mehdiour

Journal Title:Acta Scientific Cancer Biology
Abstract


Cells act as the bridges within the tissues’ territory, capable for initiating the cascade of events.Cancer is the platform of puzzles to be unmasked. There is available knowledge in cancer, but is required to be revised. However, restoration is a verbalizing item in cancer research.This commentary is aimed to highlight: 1) The protagonist and influence of “Cell Biology” and “Genetics” in the personalized cancer management, and 2) to provide the key and basic information for the clinicians who are interested in’ linking the insights’ in brief.In spite of the remarkable efforts by clinicians in cancer medicine, so far, the lack of comprehensive strategy towards cancer progression is noticeable. Bridging between Cell Biology and Genetics has an influential impact on cancer management including early detection and personalized approach in prognosis, prevention, and therapy. So, lets apply the multi-disciplinary movements in cancer managements by considering the bridging system between Cell Biology/Genetics/personalized clinical managements.Conclusively, a triangle of Single Cell, Molecular, and Pedigree-based approaches would manage the personalized strategy in cancer managements. In this regard, the application of circulating tumor cells (CTCs) for an early detection and the key impact of D1853N polymorphism in ATM gene, as a predisposing factor, are provided at a glance